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AB237759

Anti-STK33 antibody

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(1 Publication)

Rabbit Polyclonal STK33 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Serine/threonine-protein kinase 33 aa 200 to C-terminus.

View Alternative Names

Serine/threonine-protein kinase 33, STK33

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK33 antibody (AB237759)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK33 antibody (AB237759)

Paraffin-embedded human kidney tissue stained for STK33 with ab237759 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-STK33 antibody (AB237759)
  • WB

Supplier Data

Western blot - Anti-STK33 antibody (AB237759)

All lanes:

Western blot - Anti-STK33 antibody (ab237759) at 1/500 dilution

Lane 1:

Mouse kidney tissue lysate

Lane 2:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 58 kDa

false

Immunocytochemistry/ Immunofluorescence - Anti-STK33 antibody (AB237759)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-STK33 antibody (AB237759)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for STK33 (green) using ab237759 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Serine/threonine-protein kinase 33 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BYT3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK33 also known as serine/threonine kinase 33 is a nucleic protein kinase with a mass of approximately 59 kDa. The STK33 protein functions by phosphorylating serine and threonine amino acid residues which helps to regulate various cellular processes. It is broadly expressed in different tissues such as the brain lung and liver indicating its widespread importance in cellular functions.
Biological function summary

STK33 plays a role in cell proliferation and survival. While not part of any well-defined complex STK33 affects pathways associated with tumorigenic processes. It supports cellular growth by promoting cell cycle progression and inhibiting apoptosis which can lead to increased cell proliferation. These functions highlight its potential involvement in oncogenic events where dysregulation of cell growth is a common feature.

Pathways

STK33 is involved in the PI3K/AKT signaling pathway an important pathway for cell survival and metabolism. In this context STK33 interacts with proteins such as AKT and mTOR which are key components of the pathway. Additionally STK33 has connections with the MAPK/ERK pathway linking it with proteins like MEK and ERK well-known for their roles in cell proliferation and differentiation.

STK33 frequently associates with various types of cancer including lung and pancreatic cancer. Its role in promoting cell cycle progression and inhibiting apoptosis associates it with tumor survival and growth. In cancer STK33 activity connects with oncogenic proteins like KRAS influencing cancer cell metabolism and proliferation. Understanding STK33's involvement in these pathways and diseases may offer new avenues for targeted therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine/threonine protein kinase required for spermatid differentiation and male fertility (PubMed : 37146716, PubMed : 38781365). Promotes sperm flagella assembly during spermatogenesis by mediating phosphorylation of fibrous sheath proteins AKAP3 and AKAP4 (By similarity). Also phosphorylates VIME, thereby regulating the dynamic behavior of the intermediate filament cytoskeleton (By similarity).
See full target information Serine/threonine-protein kinase 33
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:756779 PubMed34745992

2021

Androgen Receptors Act as a Tumor Suppressor Gene to Suppress Hepatocellular Carcinoma Cells Progression miR-122-5p/RABL6 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Neng Tang,Xiaolin Dou,Xing You,Yixiong Li,Xi Li,Guodong Liu
View all publications
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Product promise

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