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AB238340

Anti-STK38 antibody

4

(1 Review)

|

(1 Publication)

Rabbit Polyclonal STK38 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STK38 aa 1-200.

View Alternative Names

NDR1, STK38, Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38 antibody (AB238340)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38 antibody (AB238340)

Paraffin-embedded human testis tissue stained for STK38 using ab238340 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STK38 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q15208

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Complementary Products

Primary Antibodies

AB235304

Anti-STK38L/Ndr2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Proteins & Peptides

AB101549

Recombinant human STK38 protein

Functional Studies - Recombinant human STK38 protein (AB101549)

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Primary Antibodies

AB178876

Anti-MEK1 + MEK2 antibody [EPR16667]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MEK1 + MEK2 antibody [EPR16667] (AB178876)

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  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK38 also known as NDR1 (nuclear Dbf2-related kinase 1) is a serine/threonine kinase with a molecular mass of approximately 54 kDa. It plays an important role in the regulation of cell proliferation and apoptosis through its involvement in phosphorylation processes. This protein is expressed in various tissues including the brain heart and muscle indicating its broad functional roles across different biological systems. Through its kinase activity STK38 modulates several intracellular pathways critical for maintaining cellular functions.
Biological function summary

STK38 is essential for regulating apoptosis and cell cycle progression. It acts as part of a larger signaling complex engaging in interactions with different proteins to exert its effects. Phosphorylation by STK38 often leads to activation or inhibition of downstream targets influencing cell survival and division. It can interact with MOB1 and LATS1/2 which highlights its role in the Hippo signaling pathway important for controlling organ size and suppressing tumors.

Pathways

The STK38 protein integrates itself into the Hippo and mTOR pathways. In the Hippo pathway its interactions with MOB1 and LATS proteins are important for regulating organ size and maintaining balance between cell growth and death. In the mTOR pathway STK38 influences metabolic processes and cell growth by modifying signal transduction that is critical for cellular homeostasis. These pathways are vital for normal cellular function and highlight the regulatory versatility of STK38.

STK38 plays a significant role in cancer and neurodegenerative diseases. Aberrant activity or expression levels of STK38 can contribute to the development of certain cancers due to dysregulated cell proliferation and survival. In neurodegenerative diseases improper functioning of STK38 can lead to loss of neuronal cell integrity and increased cell death. Through its interactions with cancer-related proteins such as YAP1 and neurologically relevant proteins alterations in STK38 signaling may exacerbate disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed : 12493777, PubMed : 15197186, PubMed : 17906693, PubMed : 7761441). Acts as an ufmylation 'reader' in a kinase-independent manner : specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed : 32537488).
See full target information STK38
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 14:e0225511 PubMed31756206

2019

Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Hye Sung Kim,Young Sil Kim,Chul Lee,Myung Soo Shin,Jae Wang Kim,Bo Gun Jang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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