AB235304

Anti-STK38L/Ndr2 antibody

Name: Anti-STK38L/Ndr2 antibody (ab235304) | Abcam
Brand: Abcam Limited
SKU: AB235304
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal STK38L/Ndr2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STK38L aa 200 to C-terminus.

View Alternative Names

KIAA0965, NDR2, STK38L, Serine/threonine-protein kinase 38-like, NDR2 protein kinase, Nuclear Dbf2-related kinase 2

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Paraffin-embedded human breast cancer tissue stained for STK38L/Ndr2 using ab235304 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Paraffin-embedded human thymus tissue stained for STK38L/Ndr2 using ab235304 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Paraffin-embedded human ovarian cancer tissue stained for STK38L/Ndr2 using ab235304 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-STK38L/Ndr2 antibody (AB235304)

All lanes:

Western blot - Anti-STK38L/Ndr2 antibody (ab235304) at 1/500 dilution

Lane 1:

A-375 (human malignant melanoma cell line) whole cell lysate

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

Lane 3:

A549 (human lung carcinoma cell line) whole cell lysate

Lane 4:

HCT 116 (human colorectal carcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 54 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STK38L aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2H1

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%.

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STK38L also known as Ndr2 is a member of the serine/threonine kinase family and shares similarities with other Ndr family members. This protein plays a significant mechanical role in several cellular processes including regulation of cell growth and cell division. STK38L has a molecular mass of approximately 54 kDa. Researchers have observed its expression in various human tissues such as liver kidney and heart indicating its widespread functional roles in the body.

Biological function summary

STK38L acts as an important regulator by coordinating cell cycle-related activities and influences apoptosis. It is known to participate as part of the larger signaling complex interacting with scaffold proteins to ensure proper cell function. The protein mediates these biological processes through phosphorylation impacting various signaling networks and helping cells respond to different physiological conditions effectively.

Pathways

STK38L integrates into key signaling pathways such as the Hippo pathway which is essential for controlling organ size through the regulation of cell proliferation and apoptosis. This pathway involves other proteins like MST1/2 and LATS1/2 which closely interact with STK38L to maintain cellular homeostasis. The interaction with these proteins illustrates STK38L's critical positioning in cellular communication networks affecting the pathway's outcome on cellular behavior.

STK38L is associated with certain cancers and neurodegenerative disorders. Aberrant function or regulation of STK38L may contribute to the development of conditions such as hepatocellular carcinoma and Alzheimer's disease. BRCA1 and Tau proteins are related to these diseases where STK38L's interaction with or regulation of these proteins can influence disease progression providing potential therapeutic targets for intervention.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Involved in the regulation of structural processes in differentiating and mature neuronal cells.

See full target information STK38L

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 13:1363-1376 PubMed37168348

2023

EBNA2 mediates lipid metabolism and tumorigenesis through activation of ATF4 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Feng,Ping Zhang,Paul Yao,Hongyu Zhang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-STK38L/Ndr2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK38L/Ndr2 antibody (AB235304)

Western blot - Anti-STK38L/Ndr2 antibody (AB235304)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Secondary Antibodies

Proteins & Peptides

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise