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AB229503

Anti-STOP antibody

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(1 Publication)

Rabbit Polyclonal STOP antibody. Suitable for IHC-Fr, WB and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAP6.

View Alternative Names

KIAA1878, MAP6, Microtubule-associated protein 6, MAP-6, Stable tubule-only polypeptide, STOP

3 Images
Immunohistochemistry (Frozen sections) - Anti-STOP antibody (AB229503)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-STOP antibody (AB229503)

Frozen sectioned adult mouse cerebellum stained for STOP with ab229503 (green) at a 1/250 dilution in immunohistochemical analysis. NF-H (red) and DAPI (blue).

Western blot - Anti-STOP antibody (AB229503)
  • WB

Supplier Data

Western blot - Anti-STOP antibody (AB229503)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-STOP antibody (ab229503) at 1/1000 dilution

All lanes:

Mouse brain tissue extracts at 50 µg

Predicted band size: 87 kDa

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Western blot - Anti-STOP antibody (AB229503)
  • WB

Supplier Data

Western blot - Anti-STOP antibody (AB229503)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-STOP antibody (ab229503) at 1/5000 dilution

All lanes:

Rat brain tissue extracts at 50 µg

Predicted band size: 87 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

IHC-Fr, WB

applications

Immunogen

Recombinant Fragment Protein within Human MAP6. The exact immunogen used to generate this antibody is proprietary information.

Q96JE9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/100 - 1/1000", "IHCFr-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" }, "Rat": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STOP also known as Oligophrenin-1 is a protein with a mass of approximately 88 kDa. It plays a mechanical role in the regulation of microtubule stability and dynamics. STOP is expressed in the nervous system particularly in neurons where it is involved in the cytoskeletal network. In addition to its presence in the brain STOP levels are also detectable in other tissues albeit at lower expressions compared to neuronal cells.
Biological function summary

In stabilizing microtubules STOP contributes to synaptic plasticity and proper neuronal function. As a part of the cytoskeleton regulation complex it enhances neuronal processes necessary for cognitive functions. This protein interacts with tubulin and other microtubule-associated proteins to support the structural integrity required for effective signal transmission in the nervous system.

Pathways

STOP's role in microtubule stability is integrated into neuronal growth and signaling pathways. It interacts with pathways that involve proteins such as MAP2 and Tau important for maintaining axonal transport and neuronal structure. These pathways ensure proper neuron function and are essential for brain development and neurotransmission processes.

STOP is related to neurological conditions such as schizophrenia and intellectual disabilities. Disruptions or mutations in the STOP protein can interfere with microtubule dynamics affecting neuronal stability. In disorders like schizophrenia STOP-related dysfunctions connect with abnormal interactions with proteins like CRMP2 furthering neural circuitry impairments and contributing to disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed : 24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity).
See full target information MAP6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cell 84:2320-2336.e6 PubMed38906115

2024

2'-O-methylation at internal sites on mRNA promotes mRNA stability.

Applications

Unspecified application

Species

Unspecified reactive species

Yanqiang Li,Yang Yi,Xinlei Gao,Xin Wang,Dongyu Zhao,Rui Wang,Li-Sheng Zhang,Boyang Gao,Yadong Zhang,Lili Zhang,Qi Cao,Kaifu Chen
View all publications
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Product promise

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