JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB122420

Anti-STOX1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal STOX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STOX1 aa 400-550.

View Alternative Names

C10orf24, STOX1, Storkhead-box protein 1, Winged-helix domain-containing protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-STOX1 antibody (AB122420)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-STOX1 antibody (AB122420)

Immunofluorescent staining of Human cell line U-251 MG using ab122420 at a concentration of 4 µg/ml. ab122420 staining is shown in green.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody (AB122420)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody (AB122420)

ab122420 at 1/50 dilution staining STOX1 in Paraffin-embedded Human adrenal gland tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human STOX1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.

Q6ZVD7

style
left-column

Alternative Products

Primary Antibodies

AB189436

Anti-STOX1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (AB189436)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB317579

Anti-CCXCR1/XCR1 antibody [CIA207A] - BSA and Azide free

BOND RX™ Validated|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCXCR1/XCR1 antibody [CIA207A] - BSA and Azide free (AB317579)

  • 0
  • 0
Primary Antibodies

AB244479

Anti-NKB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NKB antibody (AB244479)

  • 0
  • 0
Primary Antibodies

AB191536

Anti-PAG608 antibody

Western blot - Anti-PAG608 antibody (AB191536)

  • 0
  • 0
Primary Antibodies

AB190185

Anti-ZBTB40 antibody - C-terminal

Western blot - Anti-ZBTB40 antibody - C-terminal (AB190185)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STOX1 also known as Storkhead box protein 1 is a transcription factor with a molecular weight of approximately 53 kDa. It contains a DNA-binding domain similar to other forkhead box (FOX) family proteins. STOX1 is mainly expressed in tissues such as the placenta and antecubital skin and has a role in gene regulation through its DNA-binding capability. STOX1 helps modulate the expression of genes related to cell growth and differentiation.
Biological function summary

STOX1 functions as a regulator of oxidative stress responses and is involved in the transcriptional control of several critical genes. It does not operate as part of a larger complex but interacts directly with specific DNA sequences to exert its effects. By binding to target DNA sites STOX1 influences various biological processes including those related to homeostasis and cellular response to environmental stressors.

Pathways

STOX1 has a significant role in oxidative stress response and trophoblast differentiation pathways. It interacts with proteins such as HIF1A a factor integral to the cellular response to hypoxia demonstrating its involvement in managing oxidative stress. The pathways involving STOX1 contribute to maintaining a balance between cell survival and programmed cell death helping cells adapt to changing oxygen levels and other stresses.

STOX1 shows associations with preeclampsia and oxidative stress-related conditions. Preeclampsia a pregnancy complication characterized by high blood pressure has connections to STOX1 through its transcriptional regulation roles. During preeclampsia STOX1's expression is altered contributing to the pathophysiology of this disorder. Additionally the interaction with oxidative stress pathways ties STOX1 to conditions like chronic inflammation where it cooperates with proteins such as NRF2 an important regulator of antioxidant response.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed : 24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).. Isoform A. Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed : 22253775). Induces phosphorylation of MAPT/tau (PubMed : 22995177).
See full target information STOX1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature chemical biology 18:812-820 PubMed35484434

2022

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.

Applications

Unspecified application

Species

Unspecified reactive species

Severin Lechner,Martin Ian P Malgapo,Christian Grätz,Raphael R Steimbach,Agnes Baron,Patrick Rüther,Simon Nadal,Carmen Stumpf,Christina Loos,Xin Ku,Polina Prokofeva,Ludwig Lautenbacher,Tino Heimburg,Vivian Würf,Chen Meng,Mathias Wilhelm,Wolfgang Sippl,Karin Kleigrewe,Josch K Pauling,Karl Kramer,Aubry K Miller,Michael W Pfaffl,Maurine E Linder,Bernhard Kuster,Guillaume Médard
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com