Rabbit Polyclonal STOX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STOX1 aa 400-550.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human STOX1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZVD7
Reactivity data
Select an application| IHC-P | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.25000-2.00000 µg/mL | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). Isoform A. Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177).
Alternative names
C10orf24, STOX1, Storkhead-box protein 1, Winged-helix domain-containing protein
Recommended products
Rabbit Polyclonal STOX1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human STOX1 aa 400-550.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human STOX1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q6ZVD7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
STOX1 also known as Storkhead box protein 1 is a transcription factor with a molecular weight of approximately 53 kDa. It contains a DNA-binding domain similar to other forkhead box (FOX) family proteins. STOX1 is mainly expressed in tissues such as the placenta and antecubital skin and has a role in gene regulation through its DNA-binding capability. STOX1 helps modulate the expression of genes related to cell growth and differentiation.
- Biological function summary
STOX1 functions as a regulator of oxidative stress responses and is involved in the transcriptional control of several critical genes. It does not operate as part of a larger complex but interacts directly with specific DNA sequences to exert its effects. By binding to target DNA sites STOX1 influences various biological processes including those related to homeostasis and cellular response to environmental stressors.
- Pathways
STOX1 has a significant role in oxidative stress response and trophoblast differentiation pathways. It interacts with proteins such as HIF1A a factor integral to the cellular response to hypoxia demonstrating its involvement in managing oxidative stress. The pathways involving STOX1 contribute to maintaining a balance between cell survival and programmed cell death helping cells adapt to changing oxygen levels and other stresses.
- Associated diseases and disorders
STOX1 shows associations with preeclampsia and oxidative stress-related conditions. Preeclampsia a pregnancy complication characterized by high blood pressure has connections to STOX1 through its transcriptional regulation roles. During preeclampsia STOX1's expression is altered contributing to the pathophysiology of this disorder. Additionally the interaction with oxidative stress pathways ties STOX1 to conditions like chronic inflammation where it cooperates with proteins such as NRF2 an important regulator of antioxidant response.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody (ab122420)
ab122420 at 1/50 dilution staining STOX1 in Paraffin-embedded Human adrenal gland tissue by Immunohistochemistry.
Immunocytochemistry/ Immunofluorescence - Anti-STOX1 antibody (ab122420)
Immunofluorescent staining of Human cell line U-251 MG using ab122420 at a concentration of 4 µg/ml. ab122420 staining is shown in green.
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