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AB189436

Anti-STOX1 antibody - C-terminal

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(3 Publications)

Rabbit Polyclonal STOX1 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human STOX1.

View Alternative Names

C10orf24, STOX1, Storkhead-box protein 1, Winged-helix domain-containing protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (AB189436)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (AB189436)

Immunohistochemical analysis of formalin fixed, paraffin embedded human adrenal tissue labeling STOX1 with ab189436 at 5 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (AB189436)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STOX1 antibody - C-terminal (AB189436)

Immunohistochemical analysis of formalin fixed, paraffin embedded human skeletal muscle labeling STOX1 with ab189436 at 5 μg/ml.

Western blot - Anti-STOX1 antibody - C-terminal (AB189436)
  • WB

Supplier Data

Western blot - Anti-STOX1 antibody - C-terminal (AB189436)

All lanes:

Western blot - Anti-STOX1 antibody - C-terminal (ab189436) at 1 µg/mL

Lane 1:

Human liver lysate

Lane 2:

Human liver lysate plus blocking peptide

Predicted band size: 111 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human STOX1. The exact immunogen used to generate this antibody is proprietary information.

Q6ZVD7

Specificity

At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. ab189436 will recognize the longest isoform.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
Up to 6 months
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STOX1 also known as Storkhead box protein 1 is a transcription factor with a molecular weight of approximately 53 kDa. It contains a DNA-binding domain similar to other forkhead box (FOX) family proteins. STOX1 is mainly expressed in tissues such as the placenta and antecubital skin and has a role in gene regulation through its DNA-binding capability. STOX1 helps modulate the expression of genes related to cell growth and differentiation.
Biological function summary

STOX1 functions as a regulator of oxidative stress responses and is involved in the transcriptional control of several critical genes. It does not operate as part of a larger complex but interacts directly with specific DNA sequences to exert its effects. By binding to target DNA sites STOX1 influences various biological processes including those related to homeostasis and cellular response to environmental stressors.

Pathways

STOX1 has a significant role in oxidative stress response and trophoblast differentiation pathways. It interacts with proteins such as HIF1A a factor integral to the cellular response to hypoxia demonstrating its involvement in managing oxidative stress. The pathways involving STOX1 contribute to maintaining a balance between cell survival and programmed cell death helping cells adapt to changing oxygen levels and other stresses.

STOX1 shows associations with preeclampsia and oxidative stress-related conditions. Preeclampsia a pregnancy complication characterized by high blood pressure has connections to STOX1 through its transcriptional regulation roles. During preeclampsia STOX1's expression is altered contributing to the pathophysiology of this disorder. Additionally the interaction with oxidative stress pathways ties STOX1 to conditions like chronic inflammation where it cooperates with proteins such as NRF2 an important regulator of antioxidant response.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed : 24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity).. Isoform A. Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed : 22253775). Induces phosphorylation of MAPT/tau (PubMed : 22995177).
See full target information STOX1
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 14:e70958 PubMed40567110

2025

STOX1 Isoform A Promotes Proliferation and Progression of Hepatocellular Carcinoma by Dual Mechanisms of Transcriptionally Upregulation of Cyclin B1 and Activation of ROS-Dependent PTEN/AKT1 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Chunlin Jiang,Chong Wang,Jian Ao,Yangping Liu,Fengjie Sun,Wangpan Shi,Zeyi Guo,Yanping Wu,Luxiang Gan,Meimei Wu,Yaofeng Zhi,Zijie Meng,Wanting Wu,Juanhua Wu,Yong Ye,Xin Zhang,Dong Ren,Mingxin Pan

Protein & cell 15:419-440 PubMed38437016

2024

Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Ma,Lu Zhang,Weilong Chen,Zhaoxia Chang,Juchuanli Tu,Yuanyuan Qin,Yuwen Yao,Mengxue Dong,Jiajun Ding,Siqin Li,Fengkai Li,Qiaodan Deng,Yifei Yang,Tingting Feng,Fanrong Zhang,Xiying Shao,Xueyan He,Lixing Zhang,Guohong Hu,Quentin Liu,Yi-Zhou Jiang,Shu Zhu,Zhi Xiao,Dan Su,Tong Liu,Suling Liu

Biochemical and biophysical research communication 531:472-479 PubMed32807495

2020

circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Zhifang Li,Guiju Zhou,Fangbiao Tao,Yunxia Cao,Wenhui Han,Qing Li
View all publications
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Product promise

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