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AB111567

Anti-STRBP antibody

0

(1 Review)

|

(2 Publications)

Rabbit Polyclonal STRBP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STRBP aa 1-200.

View Alternative Names

SPNR, STRBP, Spermatid perinuclear RNA-binding protein

1 Images
Western blot - Anti-STRBP antibody (AB111567)
  • WB

Unknown

Western blot - Anti-STRBP antibody (AB111567)

7.5% SDS-PAGE.

All lanes:

Western blot - Anti-STRBP antibody (ab111567) at 1/1000 dilution

All lanes:

IMR32 whole cell lysate at 30 µg/mL

Predicted band size: 74 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human STRBP aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q96SI9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STRBP also referred to as Spermatid Perinuclear RNA Binding Protein is a protein with a molecular mass of approximately 75 kDa. STRBP binds to RNA and has been identified as having a role in the regulation of RNA metabolism. The protein shows enriched expression in the testis suggesting a role in spermatogenesis. STRBP also contains distinct RNA-binding domains which help in its interactions with various RNA molecules in the cellular environment.
Biological function summary

STRBP participates in processes linked to RNA stabilization and processing. It acts in the formation of ribonucleoprotein complexes within the cell interacting with specific RNA substrates to influence their structure and function. The protein's localization in the testis hints at its involvement in the development or function of sperm cells. Evidence suggests that STRBP contributes to post-transcriptional regulation impacting gene expression at the RNA level.

Pathways

STRBP integrates into pathways associated with RNA processing and regulation. It plays a role in the spermatogenesis pathway where it interacts with proteins like DDX4 also known as VASA a known component of the germ cell development process. STRBP's activity in these pathways is important for understanding RNA dynamics during the progression of spermatogenesis and the maintenance of germ cell integrity.

STRBP has been studied concerning its potential link to male infertility. Alterations or abnormal expression patterns of STRBP may disrupt normal spermatogenesis potentially leading to infertility issues. Additionally connections have been proposed between STRBP and another protein YBX3 known to impact RNA stability which may also contribute to reproductive dysfunctions when dysregulated. Further studies continue to elucidate STRBP's involvement in these health conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I : C) RNA than to poly(dI : dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
See full target information STRBP
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 18:4963-4983 PubMed35982909

2022

Human promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yanqun Zhang,Shenying Ji,Xiangyu Zhang,Mengyun Lu,Yihong Hu,Yucheng Han,Guanghou Shui,Sin Man Lam,Xianqiong Zou

Cell reports 31:107656 PubMed32433965

2020

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

Applications

Unspecified application

Species

Unspecified reactive species

Emily C Freund,Anne L Sapiro,Qin Li,Sandra Linder,James J Moresco,John R Yates,Jin Billy Li
View all publications
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Product promise

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