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AB237682

Anti-STRBP antibody

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(1 Publication)

Rabbit Polyclonal STRBP antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human STRBP aa 200-500.

View Alternative Names

SPNR, STRBP, Spermatid perinuclear RNA-binding protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-STRBP antibody (AB237682)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-STRBP antibody (AB237682)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for STRBP (green) using ab237682 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-STRBP antibody (AB237682)
  • WB

Supplier Data

Western blot - Anti-STRBP antibody (AB237682)

All lanes:

Western blot - Anti-STRBP antibody (ab237682)

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate

Lane 2:

PC-3 (human prostate adenocarcinoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/50000 dilution

Predicted band size: 74 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human STRBP aa 200-500. The exact immunogen used to generate this antibody is proprietary information.

Q96SI9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

STRBP also referred to as Spermatid Perinuclear RNA Binding Protein is a protein with a molecular mass of approximately 75 kDa. STRBP binds to RNA and has been identified as having a role in the regulation of RNA metabolism. The protein shows enriched expression in the testis suggesting a role in spermatogenesis. STRBP also contains distinct RNA-binding domains which help in its interactions with various RNA molecules in the cellular environment.
Biological function summary

STRBP participates in processes linked to RNA stabilization and processing. It acts in the formation of ribonucleoprotein complexes within the cell interacting with specific RNA substrates to influence their structure and function. The protein's localization in the testis hints at its involvement in the development or function of sperm cells. Evidence suggests that STRBP contributes to post-transcriptional regulation impacting gene expression at the RNA level.

Pathways

STRBP integrates into pathways associated with RNA processing and regulation. It plays a role in the spermatogenesis pathway where it interacts with proteins like DDX4 also known as VASA a known component of the germ cell development process. STRBP's activity in these pathways is important for understanding RNA dynamics during the progression of spermatogenesis and the maintenance of germ cell integrity.

STRBP has been studied concerning its potential link to male infertility. Alterations or abnormal expression patterns of STRBP may disrupt normal spermatogenesis potentially leading to infertility issues. Additionally connections have been proposed between STRBP and another protein YBX3 known to impact RNA stability which may also contribute to reproductive dysfunctions when dysregulated. Further studies continue to elucidate STRBP's involvement in these health conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I : C) RNA than to poly(dI : dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).
See full target information STRBP
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:4968-4980 PubMed36056909

2022

Risk stratification and prognosis prediction based on inflammation-related gene signature in lung squamous carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyu Zhai,Si Chen,Fangfang Duan,Junye Wang,Zerui Zhao,Yaobin Lin,Bingyu Rao,Yizhi Wang,Lie Zheng,Hao Long
View all publications
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