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AB9191

Anti-Streptococcus pyogenes Group A Carbohydrate antibody

5

(1 Review)

|

(13 Publications)

Goat Polyclonal Streptococcus pyogenes Group A Carbohydrate antibody. Carrier free. Suitable for IP, ELISA, Dot, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Streptococcus pyogenes samples. Cited in 13 publications.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Streptococcus pyogenes

Applications

WB, Dot, ELISA, IHC-P, IP, IHC-Fr, ICC/IF

applications

Specificity

Streptococcus Pyogenes Group A

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Serum was collected and antibody to the Group A carbohydrate was immunoaffinity purified
Storage buffer
pH: 7.2 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Streptococcus pyogenes Group A Carbohydrate also known as Group A strep carbohydrate acts mechanically as an important component of the cell wall in Group A Streptococcus (GAS) providing structural integrity and mediating adherence to host tissues. It consists of a rhamnose-N-acetylglucosamine polysaccharide. The carbohydrate group mass primarily composed of rhamnose is not definitively measured but its structure plays a significant role in its function. GAS expresses this carbohydrate on its surface making it accessible for interaction with the host immune system.
Biological function summary

The carbohydrate group enables Streptococcus pyogenes to interact with host tissues and evade immune detection. It is recognized as an antigen prompting the immune response by generating specific antibodies such as antistrep and antigroup antibodies. As part of the cell wall capsule the Group A carbohydrate is important for maintaining the bacterial phenotype and survival within the host. This structural component does not act alone but is associated with other cell wall proteins and elements.

Pathways

The Group A Carbohydrate plays an important role in the pathogenesis and immune evasion strategies of Streptococcus pyogenes. It does not directly involve complex metabolic pathways but is vital in the adherence and colonization processes which are more of physical pathways within the host. Its interactions influence pathways related to the immune response. Other pathogenic proteins such as M protein known for interfering with phagocytosis are associated with Group A carbohydrate through these biological functions.

Group A Streptococcus is associated with infections such as pharyngitis and rheumatic fever. The Group A carbohydrate targets the immune system impacting how antibodies recognize and respond to GAS. Rheumatic fever connects with the carbohydrate due to the cross-reactivity of host antibodies against it. Proteins like the M protein also play a role in these diseases further complicating the host-pathogen interaction and contributing to the severity of infections.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Streptococcus pyogenes Group A Carbohydrate
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Publications (13)

Recent publications for all applications. Explore the full list and refine your search

iScience 27:109623 PubMed38706859

2024

ATG9B regulates bacterial internalization via actin rearrangement.

Applications

Unspecified application

Species

Unspecified reactive species

Junpei Iibushi,Takashi Nozawa,Hirotaka Toh,Ichiro Nakagawa

PLoS pathogens 20:e1012072 PubMed38452154

2024

Streptolysin S is required for Streptococcus pyogenes nasopharyngeal and skin infection in HLA-transgenic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Blake A Shannon,Jacklyn R Hurst,Ronald S Flannagan,Heather C Craig,Aanchal Rishi,Katherine J Kasper,Stephen W Tuffs,David E Heinrichs,John K McCormick

PLoS pathogens 18:e1011013 PubMed36449535

2022

The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance.

Applications

Unspecified application

Species

Unspecified reactive species

Jacklyn R Hurst,Blake A Shannon,Heather C Craig,Aanchal Rishi,Stephen W Tuffs,John K McCormick

Nature communications 13:590 PubMed35105886

2022

PplD is a de-N-acetylase of the cell wall linkage unit of streptococcal rhamnopolysaccharides.

Applications

Unspecified application

Species

Unspecified reactive species

Jeffrey S Rush,Prakash Parajuli,Alessandro Ruda,Jian Li,Amol Arunrao Pohane,Svetlana Zamakhaeva,Mohammad M Rahman,Jennifer C Chang,Artemis Gogos,Cameron W Kenner,Gérard Lambeau,Michael J Federle,Konstantin V Korotkov,Göran Widmalm,Natalia Korotkova

Cell reports 34:108924 PubMed33789094

2021

Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.

Applications

Unspecified application

Species

Unspecified reactive species

Yujiro Hirose,Masaya Yamaguchi,Tomoko Sumitomo,Masanobu Nakata,Tomoki Hanada,Daisuke Okuzaki,Daisuke Motooka,Yasushi Mori,Hiroshi Kawasaki,Alison Coady,Satoshi Uchiyama,Masanobu Hiraoka,Raymond H Zurich,Masayuki Amagai,Victor Nizet,Shigetada Kawabata

Frontiers in immunology 11:579475 PubMed33117382

2020

Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Johann Volzke,Daniel Schultz,Marcel Kordt,Michael Müller,Wendy Bergmann,Karen Methling,Bernd Kreikemeyer,Brigitte Müller-Hilke

Nature communications 11:4697 PubMed32943639

2020

Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew K Siggins,Nicola N Lynskey,Lucy E Lamb,Louise A Johnson,Kristin K Huse,Max Pearson,Suneale Banerji,Claire E Turner,Kevin Woollard,David G Jackson,Shiranee Sriskandan

Scientific reports 10:3251 PubMed32094510

2020

Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.

Applications

Unspecified application

Species

Unspecified reactive species

Mototsugu Tanaka,Ryo Kinoshita-Daitoku,Kotaro Kiga,Takahito Sanada,Bo Zhu,Tokuju Okano,Chihiro Aikawa,Tamako Iida,Yoshitoshi Ogura,Tetsuya Hayashi,Koshu Okubo,Miho Kurosawa,Junichi Hirahashi,Toshihiko Suzuki,Ichiro Nakagawa,Masaomi Nangaku,Hitomi Mimuro

Frontiers in cellular and infection microbiology 9:398 PubMed31850237

2019

Group A NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Hirotaka Toh,Ching-Yu Lin,Shintaro Nakajima,Chihiro Aikawa,Takashi Nozawa,Ichiro Nakagawa

Autophagy 16:334-346 PubMed31177902

2019

Group A modulates RAB1- and PIK3C3 complex-dependent autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Hirotaka Toh,Takashi Nozawa,Atsuko Minowa-Nozawa,Miyako Hikichi,Shintaro Nakajima,Chihiro Aikawa,Ichiro Nakagawa
View all publications
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