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AB23501

Anti-Streptolysin antibody [6D11]

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(5 Publications)

Mouse Monoclonal TACY antibody. Suitable for ELISA and reacts with Streptococcus samples. Cited in 5 publications.

View Alternative Names

SLO, Streptolysin O, Thiol activated cytolysin

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

6D11

Isotype

IgG1

Light chain type

kappa

Carrier free

No

Reacts with

Streptococcus

Applications

ELISA

applications

Specificity

ab23501 is specific for oxidized streptolysin but cross reacts with untreated streptolysin

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Complementary Products

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Proteins & Peptides

AB63978

Recombinant Streptolysin O (Hemolytic streptococcus) protein

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Primary Antibodies

AB190467

Anti-alpha-hemolysin antibody [8B7] - N-terminal

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Primary Antibodies

AB68428

Anti-GFAP antibody [EPR1034Y] - Astrocyte Marker

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Streptococcus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "1/400", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Streptolysin is a toxin produced by certain strains of Streptococcus bacteria including the well-known Streptococcus pyogenes. This protein acts as a hemolysin creating pores in the host cell membranes leading to cell lysis. Streptolysin comes in two main forms Streptolysin O (SLO) and Streptolysin S (SLS). SLO is sensitive to oxygen and has an approximate mass of 69 to 74 kDa. Unlike SLS which is stable in the presence of oxygen. These toxins are mainly expressed during bacterial infection and play a role in promoting bacterial virulence.
Biological function summary

These hemolysins disrupt cellular integrity by forming large oligomeric pores in host cell membranes. SLO is part of the cholesterol-dependent cytolysin family requiring cholesterol-rich membranes for activity. While it is not part of a permanent complex SLO can form a temporary assembly with other molecules to execute its pore-forming function. This results in significant effects on cells and tissues infected by Streptococcus.

Pathways

Both forms of streptolysin interfere with host immune system pathways and cellular signaling. They can disrupt immune functions allowing bacteria to evade host defenses. Among the important pathways influenced by SLO is the complement pathway which plays an important role in immune response. Streptolysin can indirectly affect proteins like complement component C5a leading to reduced recruitment of immune cells to the infection site.

Streptolysin is closely linked to conditions like pharyngitis and rheumatic fever. These toxins contribute to the severe outcomes associated with these infections. Moreover streptolysin has been associated with damage to cardiac tissue in rheumatic fever possibly interacting with cardiac myosin a protein involved in heart muscle contraction. This connection makes streptolysin an interesting target for research in therapies aimed at mitigating its harmful effects.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Streptolysin
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Analytical chemistry 96:9060-9068 PubMed38701337

2024

Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in Streptolysin O.

Applications

Unspecified application

Species

Unspecified reactive species

Di Tang,Carlos Gueto-Tettay,Elisabeth Hjortswang,Joel Ströbaek,Simon Ekström,Lotta Happonen,Lars Malmström,Johan Malmström

Frontiers in cellular and infection microbiology 10:583137 PubMed33425778

2020

Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Ching-Yu Lin,Takashi Nozawa,Atsuko Minowa-Nozawa,Hirotaka Toh,Miyako Hikichi,Junpei Iibushi,Ichiro Nakagawa

Sensors (Basel, Switzerland) 12:13964-84 PubMed23202030

2012

Floating chip mounting system driven by repulsive force of permanent magnets for multiple on-site SPR immunoassay measurements.

Applications

Unspecified application

Species

Unspecified reactive species

Tsutomu Horiuchi,Tatsuya Tobita,Toru Miura,Yuzuru Iwasaki,Michiko Seyama,Suzuyo Inoue,Jun-ichi Takahashi,Tsuneyuki Haga,Emi Tamechika

Sensors (Basel, Switzerland) 12:7095-108 PubMed22969339

2012

Passive fluidic chip composed of integrated vertical capillary tubes developed for on-site SPR immunoassay analysis targeting real samples.

Applications

Unspecified application

Species

Unspecified reactive species

Tsutomu Horiuchi,Toru Miura,Yuzuru Iwasaki,Michiko Seyama,Suzuyo Inoue,Jun-ichi Takahashi,Tsuneyuki Haga,Emi Tamechika

Journal of cell science 124:2414-23 PubMed21693578

2011

Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane.

Applications

ICC/IF, WB

Species

Unspecified reactive species, Unspecified reactive species

Peter A Keyel,Lyussiena Loultcheva,Robyn Roth,Russell D Salter,Simon C Watkins,Wayne M Yokoyama,John E Heuser
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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