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AB194948

Anti-Striatin 4 antibody

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Rabbit Polyclonal Striatin 4 antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human STRN4 aa 300-400.

View Alternative Names

ZIN, STRN4, Striatin-4, Zinedin

2 Images
Western blot - Anti-Striatin 4 antibody (AB194948)
  • WB

Supplier Data

Western blot - Anti-Striatin 4 antibody (AB194948)

All lanes:

Western blot - Anti-Striatin 4 antibody (ab194948) at 0.1 µg/mL

Lane 1:

Whole cell lysate from HeLa at 50 µg

Lane 2:

Whole cell lysate from 293T at 50 µg

Lane 3:

Whole cell lysate from Jurkat at 50 µg

Lane 4:

Whole cell lysate from TCMK-1 at 50 µg

Lane 5:

Whole cell lysate from NIH 3T3 at 50 µg

Predicted band size: 80 kDa

true

Exposure time: 3min

Immunoprecipitation - Anti-Striatin 4 antibody (AB194948)
  • IP

Supplier Data

Immunoprecipitation - Anti-Striatin 4 antibody (AB194948)

Detection of Human Striatin 4 by Western Blot of Immunoprecipitates.

Lane 1 : Whole cell lysate from 293T cells (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer. ab194948 was used for IP at 6 μg per reaction, and at 0.4 μg/ml for the blot.

Lane 2 : Control IgG.

Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-Striatin 4 antibody (ab194948)

Predicted band size: 80 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IP

applications

Immunogen

Synthetic Peptide within Human STRN4 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q9NRL3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Sheep": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Striatin 4 also known as SG2NA or STRN4 is a scaffold protein with a molecular mass of approximately 100 kDa. It is part of the striatin family and plays an important role in the organization of multiprotein complexes. The protein is expressed in several tissues including the brain where it influences signaling pathways. Striatin 4 interacts with calmodulin and phosphatases facilitating communication and modification of signaling proteins.
Biological function summary

Striatin 4 facilitates interactions within the striatin family interactosome and contributes to the modulation of calcium signaling through its role in calcium/calmodulin-dependent processes. As a regulatory component it is essential within protein complexes that have wide implications in cellular signaling. The protein supports roles in cell growth apoptosis and vascular function due to its ability to bring together various signaling proteins and enzymes impacting cellular behavior.

Pathways

Researchers have identified Striatin 4 as a participant in important pathways that include the protein phosphatase 2A (PP2A) pathway and the calcium signaling pathway. Its interactions with PP2A-related proteins suggest it may serve to regulate protein dephosphorylation events thereby affecting many downstream signaling cascades. Through its participation in calcium signaling Striatin 4 works in conjunction with calcium-binding proteins influencing various physiological processes such as muscle contraction and neurotransmitter release.

Studies have linked Striatin 4 to conditions such as Alzheimer's disease and cardiovascular disorders where its role in signaling pathways may contribute to pathological changes. Its association with proteins like tau in Alzheimer's reflects its potential influence on neurodegenerative processes. Additionally the interaction of Striatin 4 with vascular-related proteins could implicate it in the progression of cardiovascular conditions making it a target of interest for disease understanding and therapeutic development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed : 18782753, PubMed : 32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed : 32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed : 32640226).
See full target information STRN4
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

Select an associated product type
Alternative Product
Primary Antibodies

AB177155

Anti-Striatin 4 antibody [EPR11801]

primary-antibodies

striatin-4-antibody-epr11801-ab177155

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