AB177155

Anti-Striatin 4 antibody [EPR11801]

RabMAb
Recombinant
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(4 Publications)

Rabbit Recombinant Monoclonal Striatin 4 antibody. Suitable for IP, WB, ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 4 publications.

View Alternative Names

ZIN, STRN4, Striatin-4, Zinedin

4 Images

Flow Cytometry (Intracellular) - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Flow Cyt (Intra)

Supplier Data

Flow Cytometry (Intracellular) - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Intracellular flow cytometric analysis of permeabilized K562cells labeling Striatin 4with ab177155 at 1/10 dilution (red), or a rabbit IgG (negative) (green).

Immunocytochemistry/ Immunofluorescence - Anti-Striatin 4 antibody [EPR11801] (AB177155)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Immunofluorescent analysis of U87-MG cells labeling Striatin 4 with ab177155 at 1/50 dilution.

Supplier Data

Immunoprecipitation - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Western blot analysis on immunoprecipitation pellet from Human fetal brain lysate, immunoprecipitated using ab177155 at 1/10 dilution.

All lanes:

Immunoprecipitation - Anti-Striatin 4 antibody [EPR11801] (ab177155)

Predicted band size: 80 kDa

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Supplier Data

Western blot - Anti-Striatin 4 antibody [EPR11801] (AB177155)

All lanes:

Western blot - Anti-Striatin 4 antibody [EPR11801] (ab177155) at 1/1000 dilution

Lane 1:

Human fetal brain tissue lysate at 10 µg

Lane 2:

K562 cell lysate at 10 µg

Lane 3:

U87-MG cell lysate at 10 µg

Lane 4:

Human cerebellum tissue lysate at 10 µg

Lane 5:

Human fetal lung tissue lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 80 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11801

Isotype

IgG

Carrier free

Reacts with

Human

Applications

Flow Cyt (Intra), ICC/IF, IP, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/10 - 1/100", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/100", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/10 - 1/100", "FlowCytIntra-species-notes": "<a href='/en-us/products/primary-antibodies/rabbit-igg-monoclonal-epr25a-isotype-control-ab172730'>ab172730</a> - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody." } } }

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Product details

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Striatin 4 also known as SG2NA or STRN4 is a scaffold protein with a molecular mass of approximately 100 kDa. It is part of the striatin family and plays an important role in the organization of multiprotein complexes. The protein is expressed in several tissues including the brain where it influences signaling pathways. Striatin 4 interacts with calmodulin and phosphatases facilitating communication and modification of signaling proteins.

Biological function summary

Striatin 4 facilitates interactions within the striatin family interactosome and contributes to the modulation of calcium signaling through its role in calcium/calmodulin-dependent processes. As a regulatory component it is essential within protein complexes that have wide implications in cellular signaling. The protein supports roles in cell growth apoptosis and vascular function due to its ability to bring together various signaling proteins and enzymes impacting cellular behavior.

Pathways

Researchers have identified Striatin 4 as a participant in important pathways that include the protein phosphatase 2A (PP2A) pathway and the calcium signaling pathway. Its interactions with PP2A-related proteins suggest it may serve to regulate protein dephosphorylation events thereby affecting many downstream signaling cascades. Through its participation in calcium signaling Striatin 4 works in conjunction with calcium-binding proteins influencing various physiological processes such as muscle contraction and neurotransmitter release.

Studies have linked Striatin 4 to conditions such as Alzheimer's disease and cardiovascular disorders where its role in signaling pathways may contribute to pathological changes. Its association with proteins like tau in Alzheimer's reflects its potential influence on neurodegenerative processes. Additionally the interaction of Striatin 4 with vascular-related proteins could implicate it in the progression of cardiovascular conditions making it a target of interest for disease understanding and therapeutic development.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed : 18782753, PubMed : 32640226). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling (PubMed : 32640226). Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). Key regulator of the expanded Hippo signaling pathway by interacting and allowing the inhibition of MAP4K kinases by the STRIPAK complex (PubMed : 32640226).

See full target information STRN4

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:12137 PubMed40204929

2025

The impact of exogenous Oxytocin on visual cortex plasticity across different stages of visual development.

Applications

Unspecified application

Species

Unspecified reactive species

Yifan Sun,Xiao Wang,Yamin Chen,Zichen Luan,Rui Hao

The EMBO journal 42:e112126 PubMed36919851

2023

Two Hippo signaling modules orchestrate liver size and tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sixian Qi,Zhenxing Zhong,Yuwen Zhu,Yebin Wang,Mingyue Ma,Yu Wang,Xincheng Liu,Ruxin Jin,Zhihan Jiao,Rui Zhu,Zhao Sha,Kyvan Dang,Ying Liu,Dae-Sik Lim,Junhao Mao,Lei Zhang,Fa-Xing Yu

Cancer cell 38:115-128.e9 PubMed32589942

2020

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Tang,Gemin Fang,Fenghua Guo,Hui Zhang,Xiaoxu Chen,Liwei An,Min Chen,Li Zhou,Wenjia Wang,Tiantian Ye,Lei Zhou,Pingping Nie,Haijun Yu,Moubin Lin,Yun Zhao,Xinhua Lin,Zengqiang Yuan,Shi Jiao,Zhaocai Zhou

eLife 9: PubMed31913126

2020

STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jong Wook Kim,Christian Berrios,Miju Kim,Amy E Schade,Guillaume Adelmant,Huwate Yeerna,Emily Damato,Amanda Balboni Iniguez,Laurence Florens,Michael P Washburn,Kim Stegmaier,Nathanael S Gray,Pablo Tamayo,Ole Gjoerup,Jarrod A Marto,James DeCaprio,William C Hahn

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Striatin 4 antibody [EPR11801]

Flow Cytometry (Intracellular) - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Immunocytochemistry/ Immunofluorescence - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Immunoprecipitation - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Western blot - Anti-Striatin 4 antibody [EPR11801] (AB177155)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Reactivity data

Product details

Properties and storage information

Form

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise