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AB155307

Anti-Sts1 antibody

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(2 Publications)

Rabbit Polyclonal Sts1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human UBASH3B aa 100 to C-terminus.

View Alternative Names

KIAA1959, STS1, UBASH3B, Ubiquitin-associated and SH3 domain-containing protein B, Cbl-interacting protein p70, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, Tyrosine-protein phosphatase STS1/TULA2, STS-1, TULA-2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sts1 antibody (AB155307)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sts1 antibody (AB155307)

Immunohistochemical analysis of paraffin-embedded Human hepatoma tissue, labeling Sts1 with ab155307 at 1/500 dilution.

Western blot - Anti-Sts1 antibody (AB155307)
  • WB

Unknown

Western blot - Anti-Sts1 antibody (AB155307)

7.5% SDS PAGE

All lanes:

Western blot - Anti-Sts1 antibody (ab155307) at 1/5000 dilution

Lane 1:

Jurkat whole cell lysate at 30 µg

Lane 2:

THP-1 whole cell lysate at 30 µg

Predicted band size: 72 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human UBASH3B aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TF42

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sts1 also known as Suppressor of T-cell receptor signaling 1 is a protein with a mass of approximately 72 kDa. It functions mechanically by serving as a negative regulator in T-cell receptor signaling pathways. Sts1 contains N-terminal SH3 domains and C-terminal ubiquitin-associated domains essential for its regulatory activity. Expression of Sts1 is widespread with notable abundance in immune cells such as T-cells and B-cells. These structural features enable Sts1 to interact with various signaling molecules.
Biological function summary

In cellular processes Sts1 plays a role in modulating immune responses. It interacts with signaling proteins including the ZAP-70 kinase which is central to T-cell receptor signaling. Sts1 forms a complex with several proteins involved in the ubiquitination process which marks proteins for degradation or alters their function. By this Sts1 influences the strength and duration of signals received by the immune cells ensuring proper immune system function.

Pathways

Sts1 serves in the T-cell receptor signaling pathway and contributes to the modulation of the immune response. The protein is closely linked to ubiquitin-proteasome system pathways which govern protein turnover and cellular regulation. In these pathways Sts1 associates with proteins like c-Cbl which are involved in the ubiquitination and degradation of signaling intermediates.

Deficiencies or dysregulation of Sts1 are often associated with autoimmune diseases and certain lymphomas. Its interplay with proteins like c-Cbl or ZAP-70 can result in aberrant T-cell activation and uncontrolled proliferation. This abnormal signaling could lead to autoimmune disorders such as systemic lupus erythematosus or contribute to the development of B-cell lymphomas where immune regulation breaks down.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
See full target information UBASH3B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 8:61604-61617 PubMed28977889

2017

Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Sangyun Shin,Hee-Jung Im,Yeo-Jung Kwon,Dong-Jin Ye,Hyoung-Seok Baek,Donghak Kim,Hyung-Kyoon Choi,Young-Jin Chun

Biomolecules & therapeutics 25:321-328 PubMed27956712

2016

Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dong-Jin Ye,Yeo-Jung Kwon,Sangyun Shin,Hyoung-Seok Baek,Dong-Won Shin,Young-Jin Chun
View all publications
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