JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB216046

Anti-STX11 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal STX11 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human STX11.

View Alternative Names

Syntaxin-11, STX11

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STX11 antibody (AB216046)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STX11 antibody (AB216046)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue tissue labeling STX11 using ab216046 at a 1/30 dilution.

Western blot - Anti-STX11 antibody (AB216046)
  • WB

Supplier Data

Western blot - Anti-STX11 antibody (AB216046)

8% SDS-PAGE

All lanes:

Western blot - Anti-STX11 antibody (ab216046) at 1/400 dilution

All lanes:

mouse lung tissue lysate at 40 µg

Predicted band size: 33 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human STX11.

O75558

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/400 - 1/2000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin 11 (STX11) is a member of the syntaxin family known as an important component in vesicle trafficking. This protein has a molecular mass of about 33 kDa. STX11 is mainly expressed in immune system cells including natural killer (NK) cells and macrophages. It plays a significant role in vesicle fusion processes by mediating the assembly and disassembly of SNARE complexes which are critical for vesicular transport and membrane fusion.
Biological function summary

Syntaxin 11 acts within the immune system to mediate secretory functions. It forms part of the SNARE complex and partners with other SNARE proteins to facilitate the exocytosis of cytotoxic granules from NK cells and cytotoxic T lymphocytes. This process is essential for immune cell-mediated destruction of infected or malignant cells. STX11 enables the regulation of immune responses by controlling vesicle docking and fusion during immune cell activation.

Pathways

The role of STX11 connects to critical immune response pathways. It plays a role in the regulation of the cytotoxic granule exocytosis pathway. This protein interacts with MUNC18-2 and other SNARE-related proteins facilitating vesicle transport and membrane fusion processes. STX11 is also involved in the modulation of pathways that oversee immune cell cytotoxicity and inflammatory responses.

Syntaxin 11 shows a connection to hemophagocytic lymphohistiocytosis (HLH) a severe immune dysregulation disorder. Alterations in STX11 have been linked to familial HLH where defective granule exocytosis impairs the immune system's ability to control inflammation leading to excessive immune activation. Interactions between STX11 and other proteins such as perforin are important in understanding HLH pathogenesis. Studies also suggest a potential connection to other immune system disorders though research continues to explore these relationships.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
See full target information STX11
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular and cellular biology 42:e0039721 PubMed35862727

2022

MicroRNA-27a-5p Inhibits Proliferation, Migration, and Invasion and Promotes Apoptosis of Wilms' Tumor Cell by Targeting PBOV1.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng-Tuan Guo,Qiang Yu,Chunlin Miao,Wenan Ge,Peng Li
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
  • 6
Proteins & Peptides

AB126662

Recombinant Human STX11 protein (denatured)

SDS-PAGE - Recombinant Human STX11 protein (denatured) (AB126662)

  • 0
  • 0
Primary Antibodies

AB317264

Anti-RAB27B antibody [EPR28647-45]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RAB27B antibody [EPR28647-45] (AB317264)

  • 0
  • 0
Primary Antibodies

AB3649

Anti-Mucin 5AC antibody [45M1]

BOND RX™ Validated|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mucin 5AC antibody [45M1] (AB3649)

  • 5
  • 8

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com