Anti-STYXL1 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

STYXL1 also known as serine/threonine/tyrosine interacting-like protein 1 and pseudo-phosphatase STYXL1 is a pseudo-phosphatase that lacks enzymatic activity due to alterations in its catalytic domain. Researchers measure its mass around 33 kDa. STYXL1 gets expressed across various tissues showing higher levels in the brain and testes. Unlike typical phosphatases STYXL1 seems to act without catalyzing dephosphorylation reactions.

Biological function summary

STYXL1 functions in regulating cellular processes despite its lack of catalytic activity. STYXL1 is associated with the regulation of cell signaling pathways and may interact with signaling proteins. It plays a role in modulating cellular communication networks by possibly scaffolding interactions rather than direct enzymatic activity. STYXL1 might exist as part of a complex where it collaborates with other proteins to mediate signaling effects.

Pathways

Researchers associate STYXL1 with the ERK/MAPK signaling pathway which controls processes such as cell division and differentiation. In this pathway STYXL1 might interact with kinases like ERK1/2 although it does not act as a traditional signaling enzyme itself. Another important pathway is the apoptosis signaling where STYXL1 impacts cellular decisions of life and death. Its pseudo-phosphatase nature could influence the pathway interactions by binding to components within these networks thereby adjusting signaling output without dephosphorylating substrates.

Associated diseases and disorders

Scientists link alterations in STYXL1 activity with cancer and neurodegenerative diseases. Abnormal expressions or mutations of STYXL1 may disrupt cell signaling pathways contributing to tumor growth and progression. In neurodegenerative conditions STYXL1 could affect neuronal survival pathways potentially involving proteins like tau where dysregulation impacts cell integrity and function. Understanding STYXL1's role in these disorders can help develop targeted therapeutic strategies.