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AB24294

Anti-SUC1 antibody [AA10.2]

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(1 Publication)

Mouse Monoclonal CKS1 antibody. Suitable for IHC, IP, WB and reacts with Schizosaccharomyces pombe samples. Cited in 1 publication.

View Alternative Names

SPBC1734.14c, suc1, Cyclin-dependent kinases regulatory subunit, P13

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

AA10.2

Isotype

IgG1

Carrier free

No

Reacts with

Schizosaccharomyces pombe

Applications

IP, IHC, WB

applications

Specificity

ab24294 can be used exclusively to capture CDK1 complexes from various cell lines and egg extracts.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Schizosaccharomyces pombe": { "IHC-species-checked": "guaranteed", "IHC-species-dilution-info": "", "IHC-species-notes": "<p></p>", "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Storage buffer
Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SUC1 protein also known as CKSHS1 has a molecular mass of approximately 13 kDa. It is mainly expressed in yeast cells particularly in the fission yeast Schizosaccharomyces pombe. Mechanically SUC1 functions as a regulatory protein that plays a role in cell cycle control by interacting with cyclin-dependent kinases (CDKs). This interaction modulates the activity of CDKs influencing their ability to phosphorylate target substrates necessary for cell cycle progression.
Biological function summary

SUC1 acts as a modulator of the cell cycle. The protein operates as part of a complex binding to and regulating CDKs which are important for the control of cell division. It ensures proper cell cycle transitions by affecting CDK activity which then governs cellular processes like DNA replication and mitosis. SUC1's role in stabilizing these interactions is indispensable for maintaining cell cycle fidelity and therefore regulates cellular proliferation.

Pathways

SUC1 integrates into the cell cycle regulation and mitotic pathways. It associates with the Cyclin-CDK complex impacting pathways that ensure accurate cell cycle checkpoints and DNA repair mechanisms. SUC1 relates specifically to pathways involving CDK1 and CDC2 proteins which are foundational for driving the cells through mitosis. The presence of SUC1 in these pathways allows it to act as an important control point influencing the stability and function of CDK complexes.

Dysregulation of SUC1 function can link to cancer and yeast cell cycle disorders. Aberrant modulation of CDK activity partly due to SUC1 malfunction disrupts the cell cycle potentially leading to uncontrolled cell proliferation seen in cancer. SUC1 interaction with CDK1 also implicates it in disorders linked to disrupted cell division and genomic instability. This connection highlights potential for targeted therapies that aim to restore normal cell cycle regulation through the modulation of SUC1 function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function.
See full target information suc1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS nano 17:8108-8122 PubMed37129374

2023

Simultaneous Detection of Tumor Derived Exosomal Protein-MicroRNA Pairs with an Exo-PROS Biosensor for Cancer Diagnosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chang-Chieh Hsu,Yunchen Yang,Eric Kannisto,Xie Zeng,Guan Yu,Santosh K Patnaik,Grace K Dy,Mary E Reid,Qiaoqiang Gan,Yun Wu
View all publications
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Product promise

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