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AB204428

Anti-SUGT1 antibody

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(1 Publication)

Rabbit Polyclonal SUGT1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SUGT1 aa 250 to C-terminus.

View Alternative Names

Protein SGT1 homolog, Protein 40-6-3, Sgt1, Suppressor of G2 allele of SKP1 homolog, SUGT1

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SUGT1 antibody (AB204428)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SUGT1 antibody (AB204428)

Immunofluorescent analysis of formalin fixed, triton X-100 permealized A431 cells labeling SUGT1 with ab204428 at 4 μg/ml (green).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SUGT1 antibody (AB204428)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SUGT1 antibody (AB204428)

Immunohistochemical analysis of formalin-fixed paraffin-embedded Human testis tissue labeling SUGT1 with ab204428 at 1/50 dilution.

Western blot - Anti-SUGT1 antibody (AB204428)
  • WB

Supplier Data

Western blot - Anti-SUGT1 antibody (AB204428)

All lanes:

Western blot - Anti-SUGT1 antibody (ab204428) at 1/100 dilution

Lane 1:

RT-4 lysate

Lane 2:

U-251 MG lysate

Lane 3:

Human plasma lysate

Lane 4:

Human liver lysate

Predicted band size: 41 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SUGT1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2Z0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SUGT1 also known as Suppressor of G2 allele of SKP1 homolog is a protein widely recognized for its role in cellular processes. It has a mass of approximately 43 kDa. Researchers typically find SUGT1 expressed in a variety of tissues with significant levels noted in the brain and reproductive organs. Its presence indicates key functions in diverse cellular environments contributing to its significance in biological research.
Biological function summary

In cellular operations SUGT1 works as a co-chaperone with HSP90 forming complexes that stabilize proteins and assist in protein folding. This interaction is critical for maintaining the proper functioning of proteins like kinases and transcription factors. SUGT1's role in forming protein complexes shows its influence in cellular stability and stress responses which helps cells combat various stresses they encounter.

Pathways

Researchers place SUGT1 within important frameworks like the Wnt signaling and kinetochore assembly pathways. In the Wnt pathway SUGT1 modulates the activity of other proteins such as beta-catenin which play roles in cell cycle regulation and embryonic development. SUGT1 associates with proteins like CCT and HSP90 via these pathways guiding processes critical for normal cell function and division.

SUGT1 involvement becomes noticeable in cancer and neurodegenerative diseases. In certain cancers altered SUGT1 activity can affect the stabilization of proteins involved in cell growth potentially leading to unchecked cell proliferation. Moreover its connection with proteins such as p53 demonstrates its role in pathways linked to cancer progression. Additionally in neurodegenerative diseases the interaction between SUGT1 and proteins like tau indicates its potential role in the pathophysiology of disorders like Alzheimer's disease highlighting the importance of understanding its functions to explore therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
See full target information SUGT1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinics (Sao Paulo, Brazil) 77:100019 PubMed35397366

2022

IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xuepu Zhang,Yue Zhang,Limin Yang,Yuexin Wu,Xiaohu Ma,Gang Tong,Zhaoliang Ban,Haosen Zhao
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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