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AB169117

Anti-SUHW1 antibody

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(1 Publication)

Mouse Polyclonal SUHW1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF280A.

View Alternative Names

SUHW1, ZNF280, ZNF636, ZNF280A, Zinc finger protein 280A, 3'OY11.1, Suppressor of hairy wing homolog 1, Zinc finger protein 636

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SUHW1 antibody (AB169117)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SUHW1 antibody (AB169117)

Immunofluorescence analysis of HeLa cells labeling SUHW1 with ab169117 at 10 ug/ml.

Western blot - Anti-SUHW1 antibody (AB169117)
  • WB

Unknown

Western blot - Anti-SUHW1 antibody (AB169117)

All lanes:

Western blot - Anti-SUHW1 antibody (ab169117) at 1 µg/mL

Lane 1:

SUHW1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

Predicted band size: 61 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ZNF280A.

P59817

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SUHW1 also known as suppressor of hairy wing is a transcription factor with a molecular mass of approximately 95 kDa. It plays a significant role in regulating gene expression by binding to specific DNA sequences. SUHW1 is expressed in various tissues including embryonic and adult cells where it functions as a DNA-binding protein influencing the transcriptional activity of numerous target genes.
Biological function summary

SUHW1 helps regulate gene silencing by forming part of a multiprotein complex. It interacts with other proteins to modulate chromatin structure ensuring that specific genes are either repressed or activated based on cellular requirements. This activity allows SUHW1 to control various processes such as development differentiation and cellular identity by adjusting the transcriptional landscape in response to internal and external signals.

Pathways

SUHW1 contributes to the transcriptional repression pathways through its interactions with other chromatin-modifying proteins. It plays an important role in the Polycomb group (PcG) pathway which helps maintain gene silencing during development. Additionally SUHW1 is linked to the Notch signaling pathway which is essential for cell fate determination. In this context SUHW1 may interact with proteins like Polycomb and other transcription factors to coordinate the regulation of target genes.

Aberrant SUHW1 expression has been observed in certain types of cancer such as leukemia where it may influence genes involved in cell cycle regulation and apoptosis. It also has potential connections to neurological disorders where dysregulation of gene expression leads to disease progression. In these cases SUHW1 might interact with other proteins like the Polycomb repressive complex to modulate pathways associated with disease development and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May function as a transcription factor.
See full target information ZNF280A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 53: PubMed41002028

2025

RNF4 and USP7 coordinate spatial regulation of SLX4 stability within the PML nuclear bodies.

Applications

Unspecified application

Species

Unspecified reactive species

Eunyoung Jung,Myung-Jin Kim,Orlando D Schärer,Yonghwan Kim
View all publications
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