Mouse Polyclonal Sulfatase 1/SULF1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SULF1.
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Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human SULF1. Database link Q8IWU6
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Mouse | Predicted |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed:12686563).
Alternative names
KIAA1077, SULF1, Extracellular sulfatase Sulf-1, hSulf-1, Arylsulfatase, N-acetylglucosamine-6-sulfatase
Recommended products
Mouse Polyclonal Sulfatase 1/SULF1 antibody. Suitable for WB and reacts with Human samples. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SULF1.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human SULF1. Database link Q8IWU6
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Sulfatase 1 also known as SULF1 or HSulf-1 is an enzyme that functions by removing sulfate groups from heparan sulfate proteoglycans. Its molecular mass is approximately 125 kDa. SULF1 is mainly expressed in the liver and it is also found in the kidney thyroid and skin tissues. It possesses a sulfatase activity that acts on the 6-O-position of heparan sulfate thereby modulating the binding sites for several growth factors.
- Biological function summary
SULF1 plays a significant role in modulating cellular processes like growth angiogenesis and tissue repair by altering the bioavailability of heparan sulfate-bound signaling molecules. It often acts as a monomer but may participate in larger complexes during functional modulation. SULF1 regulates interactions with key growth factors such as fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGFs) impacting cell communication and migration.
- Pathways
SULF1 is an important regulator in signaling pathways including the VEGF signaling pathway and the FGF signaling pathway. These pathways are essential for processes like angiogenesis and embryonic development. SULF1 activity influences these pathways by modifying heparan sulfate chains affecting the binding of FGFs and VEGFs to their respective receptors alongside related proteins like SULF2 which shares similar functions in these pathways.
- Associated diseases and disorders
SULF1's modulation of cellular signaling makes it relevant in cancer and fibrosis where aberrant signaling contributes to disease progression. Altered SULF1 expression has been associated with certain carcinomas such as hepatocellular carcinoma where it can influence tumor growth and metastasis. Additionally SULF1 interacts with proteins like matrix metalloproteinases (MMPs) which are involved in the degradation of extracellular matrix components in both tumor progression and fibrotic conditions.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Sulfatase 1/SULF1 antibody (ab168616)
All lanes: Western blot - Anti-Sulfatase 1/SULF1 antibody (ab168616) at 1 µg/mL
Lane 1: Sulfatase 1/SULF1 transfected 293T cell lysate at 15 µL
Lane 2: Non-transfected 293T cell lysate at 15 µL
SecondaryAll lanes: Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Developed using the ECL technique.
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