JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB168616

Anti-Sulfatase 1/SULF1 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal Sulfatase 1/SULF1 antibody. Suitable for WB and reacts with Transfected cell lysate - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SULF1.

View Alternative Names

KIAA1077, SULF1, Extracellular sulfatase Sulf-1, hSulf-1, Arylsulfatase, N-acetylglucosamine-6-sulfatase

1 Images
Western blot - Anti-Sulfatase 1/SULF1 antibody (AB168616)
  • WB

Unknown

Western blot - Anti-Sulfatase 1/SULF1 antibody (AB168616)

All lanes:

Western blot - Anti-Sulfatase 1/SULF1 antibody (ab168616) at 1 µg/mL

Lane 1:

Sulfatase 1/SULF1 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

true

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SULF1.

Q8IWU6

style
left-column

Alternative Products

Primary Antibodies

AB172404

Anti-Sulfatase 1/SULF1 antibody

Western blot - Anti-Sulfatase 1/SULF1 antibody (AB172404)

  • 0
  • 0
Primary Antibodies

AB32763

Anti-Sulfatase 1/SULF1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sulfatase 1/SULF1 antibody (AB32763)

  • 4
  • 5

Complementary Products

Primary Antibodies

AB52894

Anti-EGFR antibody [EP38Y]

BOND RX™ Validated|KO Validated|RabMAb|Lab Essentials|20ul selling size|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGFR antibody [EP38Y] (AB52894)

  • 5
  • 24
Primary Antibodies

AB255607

Anti-ErbB3 / HER3 antibody [EPR22669-25]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB3 / HER3 antibody [EPR22669-25] (AB255607)

  • 0
  • 0
Primary Antibodies

AB134182

Anti-ErbB2 / HER2 antibody [EP1045Y]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB2 / HER2 antibody [EP1045Y] (AB134182)

  • 4
  • 4
Primary Antibodies

AB32375

Anti-ErbB4 / HER4 antibody [E200]

RabMAb|Recombinant|20ul selling size|Trial Size

Western blot - Anti-ErbB4 / HER4 antibody [E200] (AB32375)

  • 5
  • 2
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Transfected cell lysate - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sulfatase 1 also known as SULF1 or HSulf-1 is an enzyme that functions by removing sulfate groups from heparan sulfate proteoglycans. Its molecular mass is approximately 125 kDa. SULF1 is mainly expressed in the liver and it is also found in the kidney thyroid and skin tissues. It possesses a sulfatase activity that acts on the 6-O-position of heparan sulfate thereby modulating the binding sites for several growth factors.
Biological function summary

SULF1 plays a significant role in modulating cellular processes like growth angiogenesis and tissue repair by altering the bioavailability of heparan sulfate-bound signaling molecules. It often acts as a monomer but may participate in larger complexes during functional modulation. SULF1 regulates interactions with key growth factors such as fibroblast growth factors (FGFs) and vascular endothelial growth factors (VEGFs) impacting cell communication and migration.

Pathways

SULF1 is an important regulator in signaling pathways including the VEGF signaling pathway and the FGF signaling pathway. These pathways are essential for processes like angiogenesis and embryonic development. SULF1 activity influences these pathways by modifying heparan sulfate chains affecting the binding of FGFs and VEGFs to their respective receptors alongside related proteins like SULF2 which shares similar functions in these pathways.

SULF1's modulation of cellular signaling makes it relevant in cancer and fibrosis where aberrant signaling contributes to disease progression. Altered SULF1 expression has been associated with certain carcinomas such as hepatocellular carcinoma where it can influence tumor growth and metastasis. Additionally SULF1 interacts with proteins like matrix metalloproteinases (MMPs) which are involved in the degradation of extracellular matrix components in both tumor progression and fibrotic conditions.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed : 12368295, PubMed : 12686563). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed : 12368295, PubMed : 12686563). Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (PubMed : 12686563).
See full target information SULF1
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biological research 52:60 PubMed31847887

2019

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Guangchuan Wang,Zhen Li,Xiao Li,Chunqing Zhang,Lipan Peng
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com