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AB113405

Anti-Sulfatase 2/SULF2 antibody [2B4]

3

(2 Reviews)

|

(4 Publications)

Mouse Monoclonal Sulfatase 2/SULF2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SULF2.

View Alternative Names

KIAA1247, UNQ559/PRO1120, SULF2, Extracellular sulfatase Sulf-2, hSulf-2, Arylsulfatase, N-acetylglucosamine-6-sulfatase

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sulfatase 2/SULF2 antibody [2B4] (AB113405)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sulfatase 2/SULF2 antibody [2B4] (AB113405)

Paraffin embedded HEK293 cells transfected with Sulfatase 2/SULF2 stained with ab113405.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2B4

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SULF2.

Q8IWU5

Epitope

ab113405 recognises an epitope located in the C terminal domain of Sulfatase 2/SULF2.

Specificity

ab113405 shows no cross-reactivity with Sulfatase 1

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Alternative Products

Primary Antibodies

AB232835

Anti-Sulfatase 2/SULF2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Sulfatase 2/SULF2 antibody (AB232835)

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Complementary Products

Primary Antibodies

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Anti-CD204 antibody [EPR7536]

RabMAb|Recombinant|20ul selling size

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Secondary Antibodies

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Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

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Primary Antibodies

AB205884

Anti-Syndecan 2/HSPG antibody

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Primary Antibodies

AB110635

Anti-AP2 gamma/TFAP2C antibody [3B5]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25", "IHCP-species-notes": "<p>Sodium citrate buffer pH 6.0 is recommended for this purpose.</p> Perform heat-mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sulfatase 2 (SULF2) also known as SULF-2 or extracellular sulfatase acts as an enzyme that removes sulfate groups from the heparan sulfate proteoglycans (HSPGs). It is a 100-110 kDa protein located primarily on the cell surface. SULF2's expression occurs mainly in tissues such as the liver kidney and lungs although it can be found in various other tissues too. By modifying HSPGs SULF2 influences cell signaling events that are critical to cellular communication and function.
Biological function summary

SULF2 participates in the modulation of growth factor signaling and cell surface interactions. This enzyme does not exist in isolation; instead it functions as a part of complexes involved in the extracellular matrix (ECM). Through its catalytic action SULF2 modulates the availability and activity of signaling molecules such as fibroblast growth factors (FGFs) and Wnt proteins. It impacts processes such as cell proliferation differentiation and developmental processes by altering the structural properties of the ECM.

Pathways

SULF2 significantly modulates the Wnt signaling pathway and the fibroblast growth factor receptor (FGFR) pathway. These pathways play essential roles in development and tissue regeneration. By altering the sulfation states of heparan sulfate chains SULF2 affects the interaction of proteins like Frizzled receptors in the Wnt pathway and FGFRs in the FGF signaling pathway. This modulation leads to changes in signal transduction further influencing the cellular responses during growth and development.

SULF2 has been linked with several cancer types and neurodegenerative diseases. In cancer such as hepatocellular carcinoma SULF2 overexpression promotes tumor growth and invasion by influencing growth factor signaling. It often associates with proteins like β-catenin in cancer-related pathways. In neurodegenerative diseases SULF2 modulates neural stem cell differentiation and repair influencing conditions like Alzheimer's disease. The enzyme's interaction with amyloid-beta peptides and tau protein can impact disease progression and severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed : 12368295, PubMed : 30788513, PubMed : 35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed : 12368295, PubMed : 30788513, PubMed : 35294879).
See full target information SULF2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Acta biochimica Polonica 68:217-222 PubMed34033710

2021

The upregulation of miR-204-3p in LPS-induced acute lung injury aggravated pulmonary endothelial cells apoptosis via targeting sulfatase 2.

Applications

Unspecified application

Species

Unspecified reactive species

Liya Zhang,Zhengyu Zhu,Qian Zhang,Zhengdao Mao

Experimental eye research 207:108553 PubMed33811915

2021

ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration.

Applications

Unspecified application

Species

Unspecified reactive species

Michael J Gilhooley,Doron G Hickey,Moritz Lindner,Teele Palumaa,Steven Hughes,Stuart N Peirson,Robert E MacLaren,Mark W Hankins

Nature communications 12:1923 PubMed33772011

2021

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.

Applications

Unspecified application

Species

Unspecified reactive species

Darpan Saraswat,Hani J Shayya,Jessie J Polanco,Ajai Tripathi,R Ross Welliver,Suyog U Pol,Richard A Seidman,Jacqueline E Broome,Melanie A O'Bara,Toin H van Kuppervelt,Joanna J Phillips,Ranjan Dutta,Fraser J Sim

Oncogene 29:635-46 PubMed19855436

2009

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

H Lemjabbar-Alaoui,A van Zante,M S Singer,Q Xue,Y-Q Wang,D Tsay,B He,D M Jablons,S D Rosen
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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