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AB235783

Anti-SULT1B1 antibody

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(1 Publication)

Rabbit Polyclonal SULT1B1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SULT1B1 aa 1 to C-terminus.

View Alternative Names

ST1B2, SULT1B2, SULT1B1, Sulfotransferase 1B1, ST1B1, Sulfotransferase 1B2, Sulfotransferase family cytosolic 1B member 1, Thyroid hormone sulfotransferase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1B1 antibody (AB235783)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT1B1 antibody (AB235783)

Paraffin-embedded human small intestine tissue stained for SULT1B1 using ab235783 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-SULT1B1 antibody (AB235783)
  • WB

Supplier Data

Western blot - Anti-SULT1B1 antibody (AB235783)

All lanes:

Western blot - Anti-SULT1B1 antibody (ab235783) at 1/500 dilution

All lanes:

Mouse small intestine tissue

Secondary

All lanes:

Goat polyclonal to rabbit IgG at 1/10000 dilution

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SULT1B1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43704

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Secondary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity >95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SULT1B1 also known as Sulfotransferase Family 1B Member 1 is an enzyme that belongs to the sulfotransferase family. It has a molecular weight of approximately 34 kDa. This enzyme is mainly expressed in the liver and small intestine with some presence in the colon and brain. SULT1B1 participates in the sulfation process where it transfers a sulfo group to phenolic compounds aiding in their metabolism and detoxification.
Biological function summary

Sulfotransferases like SULT1B1 are essential for the modulation and detoxification of hormones drugs and xenobiotics. This process plays an important role in maintaining balance within the body. While not known to form part of large complexes SULT1B1 works individually on its substrates altering their biological activity and solubility. This metabolic function ensures regulated activity and excretion of various compounds from the body.

Pathways

SULT1B1 participates in both xenobiotic metabolism and hormone regulation pathways. In the context of xenobiotic metabolism SULT1B1 alongside enzymes like Cytochrome P450s carries out phase II reactions facilitating the elimination of foreign compounds from the body. In hormone regulation SULT1B1's function is to inactivate hormones such as thyroid hormones rendering them less active and promoting their clearance from circulation.

Aberrant activity or expression of SULT1B1 might relate to colorectal cancer and thyroid hormone imbalances. Altered sulfotransferase activity affects hormone regulation contributing to disorders like hypothyroidism. Additionally disruptions may link to other pathways involving proteins such as deiodinases in thyroid regulation emphasizing the importance of balanced sulfation activity in maintaining hormone homeostasis and preventing disease development.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed : 28084139, PubMed : 9443824, PubMed : 9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed : 35165440).
See full target information SULT1B1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

OncoTargets and therapy 14:3721-3728 PubMed34140780

2021

G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yunfen Li,Zhengting Chen,Ke Cao,Lan Zhang,Yuhui Ma,Shuhui Yu,Hanyu Jin,Xiaoling Liu,Wenhui Li
View all publications
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Product promise

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