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AB212838

Anti-Sumo 2 antibody [SPM621] - BSA and Azide free

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(3 Publications)

Mouse Monoclonal Sumo 2 antibody. Carrier free. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SUMO2.

View Alternative Names

SMT3B, SMT3H2, SUMO2, Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, Smt3B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sumo 2 antibody [SPM621] - BSA and Azide free (AB212838)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sumo 2 antibody [SPM621] - BSA and Azide free (AB212838)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for Sumo 2 using ab212838 at 1 μg/ml in immnohistochemical analysis.

This IHC-P data was generated using the same anti-Sumo 2 antibody clone, SPM621, in a different buffer formulation.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

SPM621

Isotype

IgG1

Light chain type

kappa

Carrier free

Yes

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human SUMO2.

P61956

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>(Primary incubation for 30 minutes at RT).</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
ab212838 was purified from bioreactor concentrate by protein A/G.
Storage buffer
pH: 7.2 - 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Sumo 2 also known as SUMO-2 or SMT3A is a small ubiquitin-like modifier protein with a molecular mass of approximately 11 kDa. It belongs to the SUMO protein family which includes SUMO-1 SUMO-3 and others. Sumo 2 is widely expressed in the nucleus and cytoplasm of eukaryotic cells. It is involved in the post-translational modification process known as SUMOylation where it covalently attaches to specific lysine residues on substrate proteins influencing their activity localization and stability.
Biological function summary

Sumo 2 influences various cellular processes including nuclear-cytosolic transport transcriptional regulation and protein stability. It often forms part of multi-protein complexes showing versatility in regulating cellular responses to stress and maintaining protein homeostasis. Sumo 2's dynamic attachment and detachment from its target proteins allow fine-tuning of cellular pathways reflecting its essential role in managing cellular conditions.

Pathways

Sumo 2 participates in the DNA damage response and the heat shock response pathways. Its involvement helps ensure proper cell cycle progression and stress response through interaction with key proteins like p53 and HSF1. Sumo 2 modification alters the activity of these proteins and others affecting cell survival under stress conditions and facilitating DNA repair mechanisms showing its comprehensive integration in these important cellular processes.

Alterations in Sumo 2 function have links to neurodegenerative diseases and cancer. Abnormal SUMOylation patterns involving Sumo 2 correlate with the progression of Alzheimer's disease and various types of tumors. In these contexts Sumo 2 modulates proteins such as tau and MDM2 which are critical in disease development and progression. Exploring the role of Sumo 2 in these conditions highlights its potential as a target for therapeutic intervention and diagnostic applications.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed : 26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed : 18408734, PubMed : 18538659, PubMed : 21965678, PubMed : 9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed : 24105744).
See full target information SUMO2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 24:631 PubMed36160893

2022

Mediastinal cavernous angioleiomyoma: A case report and review of literature.

Applications

Unspecified application

Species

Unspecified reactive species

Zhibo Zuo,Wanxin Wu,Xin Li,Lin Zhang,Jingyu Wang,Zhiqin Guo,Shaoqing Hu,Qi Zhang

Cells 10: PubMed33477333

2021

SUMO-Activating Enzyme Subunit 1 (SAE1) Is a Promising Diagnostic Cancer Metabolism Biomarker of Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jiann Ruey Ong,Oluwaseun Adebayo Bamodu,Nguyen Viet Khang,Yen-Kuang Lin,Chi-Tai Yeh,Wei-Hwa Lee,Yih-Giun Cherng

PLoS pathogens 13:e1006262 PubMed28253371

2017

Autophagy regulates UBC9 levels during viral-mediated tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Domenico Mattoscio,Chiara Casadio,Claudia Miccolo,Fausto Maffini,Andrea Raimondi,Carlo Tacchetti,Tarik Gheit,Marta Tagliabue,Viviana E Galimberti,Francesca De Lorenzi,Michael Pawlita,Fausto Chiesa,Mohssen Ansarin,Massimo Tommasino,Susanna Chiocca
View all publications
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Product promise

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