Rabbit Polyclonal SUN2 antibody. Suitable for ICC and reacts with Mouse samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Mouse Sun2 aa 1-50.
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- Journal of lipid research 63:1002772022Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCecilia Östlund,Antonio Hernandez-Ono,Samantha J Turk,William T Dauer,Henry N Ginsberg,Howard J Worman,Ji-Yeon ShinPubMed 36100089
- Nature communications 13:30532022Characterisation of a nucleo-adhesome.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAdam Byron,Billie G C Griffith,Ana Herrero,Alexander E P Loftus,Emma S Koeleman,Linda Kogerman,John C Dawson,Niamh McGivern,Jayne Culley,Graeme R Grimes,Bryan Serrels,Alex von Kriegsheim,Valerie G Brunton,Margaret C FramePubMed 35650196
- Developmental cell 51:602-616.e122019ERK1/2 Phosphorylation of FHOD Connects Signaling and Nuclear Positioning Alternations in Cardiac Laminopathy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSusumu Antoku,Wei Wu,Leroy C Joseph,John P Morrow,Howard J Worman,Gregg G GundersenPubMed 31794718
- Current biology : CB 27:3097-3110.e52017Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRuijun Zhu et. al.PubMed 28988861
- Molecular cancer research : MCR 15:1579-15862017Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhe Yang et. al.PubMed 28811362
- The Journal of cell biology 216:657-6742017TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCosmo A Saunders et. al.PubMed 28242745
- Molecular biology of the cell 26:3379-892015Lamins position the nuclear pores and centrosomes by modulating dynein.
- The EMBO journal 34:1875-882015Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAna Gutiérrez-Fernández et. al.PubMed 25991604
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Mouse Sun2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q8BJS4
Reactivity data
Select an application| ICC | |
|---|---|
| Mouse | Tested |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info - | Notes - |
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Target data
Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5.
Alternative names
Unc84b, Sun2, SUN domain-containing protein 2, Protein unc-84 homolog B, Sad1/unc-84 protein-like 2
Recommended products
Rabbit Polyclonal SUN2 antibody. Suitable for ICC and reacts with Mouse samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Mouse Sun2 aa 1-50.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.1% Sodium azide
Constituents: Whole serum- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Mouse Sun2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information. Database link Q8BJS4
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SUN2 also known as Sad1 and UNC84 domain containing 2 is a protein that plays a fundamental role in the positioning of the nucleus in cells. It has a mass of approximately 89 kDa. This protein localizes to the inner nuclear membrane where it is involved in tethering the nucleus to the cytoskeleton. SUN2 is mainly expressed in tissues exhibiting high mechanical stress such as muscle and bone tissue. Its structural role anchors the nuclear lamina to the cytoskeleton helping to maintain cellular integrity.
- Biological function summary
SUN2 connects the nuclear interior with the cytoskeleton through the LINC complex (Linker of Nucleoskeleton and Cytoskeleton). This complex also includes other proteins like Nesprin and Lamins helping to transmit mechanical signals across the nuclear envelope. SUN2 plays an essential role in processes like cell division nuclear migration and chromosomal positioning. Its function in the LINC complex makes it a significant player in maintaining nuclear morphology and ensuring proper cell division.
- Pathways
SUN2 is involved in the mechanotransduction and cell-cycle regulation pathways. In mechanotransduction SUN2 helps translate mechanical signals into biochemical ones therefore influencing gene expression. Related proteins like Nesprin-2 interact within the LINC complex and contribute to these pathways. In cell-cycle regulation the protein helps align the mitotic spindle through connection with components of the cytoskeleton supporting accurate cell division. These pathways demonstrate SUN2's contribution to cellular responses to mechanical stimuli and cell growth regulation.
- Associated diseases and disorders
Studies indicate that SUN2 mutations or abnormal expression levels are associated with muscular dystrophy and cancer. In muscular dystrophy defects in SUN2 can lead to impaired nuclear anchoring contributing to muscle weakness. It interacts with Lamin A/C and defects in these proteins are also linked to muscular dystrophies. In cancer SUN2 dysregulation may affect cellular architecture and chromosomal stability contributing to tumorigenesis. Understanding SUN2's roles and interactions offers potential pathways for therapeutic interventions.
Product promise
Tested
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Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunocytochemistry - Anti-SUN2 antibody (ab87036)
Immunocytochemistry analysis of NIH 3T3 cells labelling SUN2 with ab87036 at 1/500 dilution.
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