Anti-SUN3 antibody [EPR12910] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SUN3 also known as Sad1 and UNC-like domain-containing protein 3 has a molecular mass of approximately 115 kDa. This protein is mechanistically involved in nuclear envelope organization and is predominantly expressed in testicular tissue specifically within spermatogenic cells. It localizes to the nuclear envelope where it is believed to contribute to the structural integrity and function of the nuclear membrane.

Biological function summary

SUN3 is involved in the formation of the LINC complex which stands for LInker of NucleOcytoskeleton Complex. This complex serves as a bridge between the nucleoskeleton and the cytoskeleton. Through this connection SUN3 assists in maintaining nuclear positioning and stability playing a role in the mechanical coupling of the nucleus with cytoskeletal elements. This interaction is essential for processes like spermatogenesis where nuclear movement and positioning are key.

Pathways

SUN3 participates in the spermatogenesis and meiotic cell division processes. The LINC complex including SUN3 partners with proteins such as KASH5 in these pathways to ensure proper chromosomal movement and alignment. Its role in these pathways is critical for normal fertility as errors can lead to abnormal sperm development and function.

Associated diseases and disorders

Alterations in the function or expression of SUN3 affect male fertility leading to conditions such as oligozoospermia or asthenozoospermia. These conditions arise when the structural and positional integrity of the sperm nucleus is compromised. SUN3 interactions with proteins like KASH5 are significant because any disruption can result in impaired spermatogenesis contributing to these fertility issues.