Anti-Superoxide Dismutase 1 antibody
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(23 Reviews)
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(232 Publications)
Anti-Superoxide Dismutase 1 antibody (ab13498) is a rabbit polyclonal antibody for Western Blot, IP, IHC-P, IHC-Fr, ICC/IF, ELISA. Suitable for Coral, Cow, Dog, Drosophila, Fish, Hamster, Human, Mollusk, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus.
- Over 190 publications
- Trusted since 2004
View Alternative Names
Superoxide dismutase [Cu-Zn], Hydrogen sulfide oxidase, Superoxide dismutase 1, hSod1, SOD1
- WB
Supplier Data
Western blot - Anti-Superoxide Dismutase 1 antibody (AB13498)
Block : 1.5% BSA.
All lanes:
Western blot - Anti-Superoxide Dismutase 1 antibody (ab13498) at 0.2 µg/mL
All lanes:
HeLa (Human epithelial cell line from cervix adenocarcinoma) lysate at 15 µg
Secondary
All lanes:
Donkey Anti-Rabbit IgG HRP 1 hr at RT
Predicted band size: 15 kDa
Observed band size: 23 kDa
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- WB
CiteAb
Western blot - Anti-Superoxide Dismutase 1 antibody (AB13498)
Western Blotting using Anti-Superoxide Dismutase 1 antibody, ab13498. Publication image from Liu, Y. et al., 2018, Nat Commun, 30356100. Legend direct from paper.
HPV16 E7-induced LDHA nuclear translocation implicates in cervical cancer development. a, b, c LDHANLS increases tumor growth in xenograft nude mice model. Representative images (mouse NO. 1 with Vec on the left flank and WT on the right flank, and mouse NO. 1′ with NLS on the left flank and NES on the right flank) of HeLa LDHA KO with Vec/WT/NLS/NES putback xenograft mice (a). Dissected tumors in xenograft mice transplanted with HeLa LDHA KO with Vec/WT/NLS/NES putback cells (b) and the tumor volumes on day 30 were represented (c). d LDHANLS tumor shows an elevated H3K79me2, NRF2, SOD1, and MYC levels. The level of H3K79me2 and the expression of NRF2, SOD1, and MYC in two pairs of representative tumors were analyzed by western blotting. β-actin and histone H3 were used as loading control. e LDHA nuclear translocation are positively correlated with H3K79 trimethylation in K14-HPV16 transgenic mice. Representative IHC images of HPV16 E7 expression, LDHA localization, and H3K79me3 level at indicated time point in TALEN-mediated targeting E7 of K14-HPV16 transgenic mice. n = 3 per group. Scale bar, 50 µm. f HPV16 E7 levels, LDHA nuclear translocation and H3K79 trimethylation are positively correlated with each other in human cervical tumor tissues. The 52 cases were divided into four groups on the basis of their tumor HPV16 E7 expression scores. Horizontal lines represent the median. Data are shown as mean ± SEM. The p values were determined by two-tailed t-test. The values of p < 0.05 were considered statistically significant. *, **, and *** denote p < 0.05, p < 0.01, and p < 0.001, respectively. NS means non significant. g Proposed molecular mechanism model of a noncanonical role for LDHA in responds to HR-HPV infection. PYR, pyruvate, LAC, lactate,α-KB,α-ketobutyrate, andα-HB,α-hydroxybutyrate
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Reactivity data
Product details
Anti-Superoxide Dismutase 1 antibody (ab13498) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in African green monkey, Coral, Cow, Dog, Drosophila melanogaster, Fish, Hamster, Human, Mollusk, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus laevis samples.
What is the molecular weight of Superoxide Dismutase 1?
Anti-Superoxide Dismutase 1 (ab13498) specifically detects a band for Superoxide Dismutase 1 (UniProt: P00441) at a molecular weight of 16kDa.
Trusted by the scientific community
Anti-Superoxide Dismutase 1 (ab13498) was first used in a scientific publication in 2004 and has been cited over 190 times in peer-reviewed journals.
Reviewed by scientists
Anti-Superoxide Dismutase 1 (ab13498) has over 20 independent reviews from customers.
Properties and storage information
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Purification technique
Purification notes
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Shipped at conditions
Appropriate short-term storage duration
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Appropriate long-term storage conditions
Aliquoting information
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The enzyme functions as a homodimer with each subunit containing a copper and zinc ion. These metal ions are essential for the catalytic activity of SOD1 as the copper ion participates in electron transfer while the zinc ion provides structural stability. The enzyme protects cells from oxidative stress by neutralizing excess reactive oxygen species ensuring cellular health and functioning.
Pathways
SOD1 plays an important role in the cellular antioxidant defense system and is a part of the reactive oxygen species (ROS) metabolic pathway. It works in conjunction with catalase and glutathione peroxidase to limit oxidative damage within cells. The close interaction between these enzymes highlights the interdependence within the antioxidant defense network emphasizing their role in maintaining cellular homeostasis.
Product protocols
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Target data
Publications (232)
Recent publications for all applications. Explore the full list and refine your search
Cell biology and toxicology 41:129 PubMed40897829
2025
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Comprehensive Physiology 15:e70031 PubMed40765038
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Alzheimer's & dementia : the journal of the Alzheimer's Association 21:e70117 PubMed40189792
2025
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PloS one 20:e0313803 PubMed40173155
2025
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Investigative ophthalmology & visual science 66:60 PubMed39992672
2025
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The journal of headache and pain 25:207 PubMed39587478
2024
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International journal of molecular sciences 25: PubMed39408720
2024
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Pharmaceuticals (Basel, Switzerland) 17: PubMed39338355
2024
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Acta neuropathologica communications 12:144 PubMed39227882
2024
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Journal of virology 98:e0126224 PubMed39194237
2024
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Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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