Anti-SUPT4H antibody [3079C1a]

Target data

Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II (PubMed : 10075709, PubMed : 10199401, PubMed : 10454543, PubMed : 10912001, PubMed : 11112772, PubMed : 11553615, PubMed : 12653964, PubMed : 12718890, PubMed : 15136722, PubMed : 15380072, PubMed : 9450929, PubMed : 9857195). DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A (PubMed : 15136722). DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter (PubMed : 10199401, PubMed : 10912001, PubMed : 11112772). Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex (PubMed : 10199401, PubMed : 10912001, PubMed : 11112772). DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II (PubMed : 10199401, PubMed : 10912001, PubMed : 11112772). TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme (PubMed : 16214896). Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (PubMed : 16214896). DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat (PubMed : 11112772). DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences (PubMed : 11112772).