Anti-SUR1 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

SUR1 binds with the Kir6.2 channel subunits to form functional K_ATP channel complexes. These channels respond to intracellular ATP and ADP levels providing a critical link between cellular energy metabolism and electric cell function. In pancreatic beta cells the opening and closing of these channels trigger the release of insulin in response to blood glucose levels. In the brain the channels modulate neuronal excitability and play a role in neuroprotection. The coupling with Kir6.2 emphasizes the role of the SUR1-Kir6.2 complex in many cellular processes.

Pathways

The K_ATP channels containing SUR1 participate in the insulin secretion pathway and the cellular response to hypoxia. The insulin secretion pathway is important for glucose homeostasis where SUR1 interacts with proteins like Kir6.2 directly linking glucose metabolism to insulin release. In the cellular response to hypoxia SUR1 influences neuronal survival by modifying cell membrane potential regulating excitability and managing cellular energy usage in low oxygen conditions. These pathways demonstrate the importance of SUR1 in maintaining energy balance within cells and across organs.