Rabbit Polyclonal SURF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SURF1 aa 50 to C-terminus.
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Publications
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- Nature communications 13:36152022Coordination of metal center biogenesis in human cytochrome c oxidase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEva Nývltová,Jonathan V Dietz,Javier Seravalli,Oleh Khalimonchuk,Antoni BarrientosPubMed 35750769
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SURF1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q15526
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
Alternative names
SURF-1, SURF1, Surfeit locus protein 1
Recommended products
Rabbit Polyclonal SURF1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SURF1 aa 50 to C-terminus.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SURF1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link Q15526
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Surf1 also known as SURF1 homolog or SURF1 cytochrome c oxidase assembly protein has a molecular mass of approximately 33 kDa. It localizes mainly in the inner mitochondrial membrane of eukaryotic cells. The expression of Surf1 is widespread found in tissues with high metabolic demand like the heart brain and skeletal muscle. Surf1 plays an important role in the proper functioning of mitochondria which are the powerhouses of the cell generating energy in the form of ATP.
- Biological function summary
Surf1 assists in the assembly of cytochrome c oxidase (COX) the last enzyme in the mitochondrial respiratory chain complex IV. It interacts with various subunits of the COX complex ensuring their proper assembly and stability within the inner mitochondrial membrane. Through its role in COX assembly Surf1 supports efficient electron transport and energy production which is critical for cellular respiration.
- Pathways
Surf1 contributes to electron transport chain pathways and oxidative phosphorylation. It facilitates the integration of COX subunits into a functional complex. Surf1 interacts with other mitochondrial proteins like COX10 and COX15 which are involved in heme A biosynthesis a critical component of COX. Together these proteins ensure the efficient production and transfer of ATP maintaining cellular energy balance.
- Associated diseases and disorders
Surf1 mutations relate strongly to Leigh syndrome a severe neurological disorder. This disorder results from defective energy production due to impaired cytochrome c oxidase assembly. Children with Leigh syndrome often exhibit symptoms like movement disorders and brain abnormalities. Surf1 abnormalities can also connect with other conditions involving compromised mitochondrial function linking it to proteins involved in mitochondrial maintenance and function such as NDUFS4. These associations emphasize the significance of Surf1 in maintaining cellular health and energy production.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-Surf1 antibody (ab155251)
12% SDS PAGE
All lanes: Western blot - Anti-Surf1 antibody (ab155251) at 1/3000 dilution
All lanes: Jurkat whole cell lysate at 30 µg
Predicted band size: 33 kDa
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