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AB127909

Anti-SUV3L1 antibody

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(2 Publications)

Rabbit Polyclonal SUV3L1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SUPV3L1 aa 500-750.

View Alternative Names

SUV3, SUPV3L1, Suppressor of var1 3-like protein 1, SUV3-like protein 1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SUV3L1 antibody (AB127909)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SUV3L1 antibody (AB127909)

ab127909 at 1/500 dilution staining SUV3L1 in methanol-fixed HeLa cells by confocal Immunofluorescence. Alpha-tubulin filaments are stained in red.

Western blot - Anti-SUV3L1 antibody (AB127909)
  • WB

Unknown

Western blot - Anti-SUV3L1 antibody (AB127909)

7.5% SDS PAGE

All lanes:

Western blot - Anti-SUV3L1 antibody (ab127909) at 1/1000 dilution

All lanes:

PC3 whole cell lysate at 30 µg

Predicted band size: 88 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human SUPV3L1 aa 500-750. The exact immunogen used to generate this antibody is proprietary information.

Q8IYB8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab127909 is purified by antigen-affinity chromatography.
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SUV3L1 also known as Suppressor of Var1 3-Like 1 is an ATP-dependent RNA helicase with a mass of approximately 90 kDa. Mechanically it unwinds RNA and participates in RNA processing and surveillance ensuring the integrity of RNA molecules. SUV3L1 exhibits a wide expression pattern being found in various tissues predominantly in regions with high mitochondrial activity due to its critical role in RNA metabolism.
Biological function summary

The helicase activity of SUV3L1 plays an important role in mitochondrial RNA degradation. SUV3L1 forms a functional complex with polynucleotide phosphorylase (PNPase) and together they contribute to mitochondrial RNA processing and decay. This complex is vital for maintaining mitochondrial RNA homeostasis and ensuring proper mitochondrial function affecting mitochondrial biogenesis and energy production.

Pathways

It is involved in mitochondrial gene expression and respiratory chain assembly. In the context of regulated RNA decay pathways SUV3L1 acts alongside PNPase to maintain proper levels of mitochondrial transcripts impacting cellular energy balance. Furthermore SUV3L1 is connected to the mitochondrial DNA transcription pathway where it associates with mitochondrial transcription factor B2 (TFB2M) enhancing the stability of mitochondrial transcripts and ensuring the effective production of mitochondrial proteins.

SUV3L1 has been implicated in mitochondrial disorders and certain types of cancer. Alterations in its function can lead to disrupted mitochondrial biogenesis contributing to disorders characterized by impaired mitochondrial activity. Research shows that SUV3L1 interacts with proteins like POLRMT which is part of the mitochondrial transcription machinery linking its dysregulation to mitochondrial-related dysfunctions and tumorigenesis. Understanding these associations helps illuminate SUV3L1's role in disease pathogenesis and potential therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed : 29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
See full target information SUPV3L1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 8: PubMed40523799

2025

Transcription arrest induces formation of RNA granules in mitochondria.

Applications

Unspecified application

Species

Unspecified reactive species

Katja G Hansen,Autum Baxter-Koenigs,Caroline Am Weiss,Erik McShane,L Stirling Churchman

Cell 153:101-11 PubMed23540693

2013

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ruchi Shukla,Kyle R Upton,Martin Muñoz-Lopez,Daniel J Gerhardt,Malcolm E Fisher,Thu Nguyen,Paul M Brennan,J Kenneth Baillie,Agnese Collino,Serena Ghisletti,Shruti Sinha,Fabio Iannelli,Enrico Radaelli,Alexandre Dos Santos,Delphine Rapoud,Catherine Guettier,Didier Samuel,Gioacchino Natoli,Piero Carninci,Francesca D Ciccarelli,Jose Luis Garcia-Perez,Jamila Faivre,Geoffrey J Faulkner
View all publications
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