Rabbit Polyclonal NRAM antibody. Suitable for ELISA and reacts with Synthetic peptide - Influenza A virus (A/California/14/2009(H1N1)) samples.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Reactivity data
Select an application| ELISA | |
|---|---|
| Influenza A virus (A/California/14/2009(H1N1)) | Predicted |
| Synthetic peptide - Influenza A virus (A/California/14/2009(H1N1)) | Tested |
ELISA
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Synthetic peptide - Influenza A virus (A/California/14/2009(H1N1)) | Dilution info 1 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Influenza A virus (A/California/14/2009(H1N1)) | Dilution info - | Notes - |
Target data
Function
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
Alternative names
Neuraminidase, NA
Recommended products
Rabbit Polyclonal NRAM antibody. Suitable for ELISA and reacts with Synthetic peptide - Influenza A virus (A/California/14/2009(H1N1)) samples.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Purification technique
- Affinity purification Immunogen
- Specificity
Specific for the novel S-OIV A H1N1 strain Neuraminidase and will not recognize the corresponding Neuraminidase sequence from the seasonal H1N1 influenza (A/Georgia/20/2006 (H1N1)).
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Swine H1N1 Neuraminidase also known as Sialidase is an enzyme that catalyzes the hydrolysis of terminal sialic acid residues from glycoproteins and glycolipids. It has a molecular mass of approximately 60 kDa. This enzyme appears on the surface of the Influenza A virus including swine flu strains. Neuraminidase plays a critical mechanical role in the viral life cycle by facilitating the release of progeny virus from infected host cells.
- Biological function summary
In the context of the influenza virus Swine H1N1 Neuraminidase contributes to the spread of infection by breaking down mucins in the respiratory tract helping the virus to penetrate host cells. This protein functions as part of a complex with hemagglutinin another viral surface protein ensuring the continuity of virus attachment and release processes. This complementary interaction between neuraminidase and hemagglutinin supports efficient viral entry and exit maintaining the infection cycle.
- Pathways
Swine H1N1 Neuraminidase is significant in two main biological pathways: viral entry and viral release from host cells. Neuraminidase breaks the link between viruses and the sialic acid residues present on host cell surfaces facilitating the budding of new viral particles. Hemagglutinin closely related through these pathways mediates initial binding and fusion with host membranes while neuraminidase functions to clear released viruses from decoy sites making them ready to infect new cells.
- Associated diseases and disorders
Neuraminidase from Swine H1N1 is an important factor in the pathogenesis of swine flu and related influenza pandemics. The activity of neuraminidase in coordination with hemagglutinin ensures the efficiency of viral infection and replication contributing to respiratory infections in humans and swine. Therapeutics targeting neuraminidase such as oseltamivir are important in controlling the spread and impact of these influenza types highlighting its role in antiviral treatment strategies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
ELISA - Anti-Swine H1N1 Neuraminidase antibody (ab91643)
ELISA using ab91643 at 1 μg/ml. Detects 2ng of Swine H1N1 Neuraminidase peptide.
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