AB8

Anti-Synapsin I antibody - Synaptic Marker

Name: Anti-Synapsin I antibody - Synaptic Marker (ab8) | Abcam
Brand: Abcam Limited
SKU: AB8
Price: 645 USD
Availability: InStock
Rating: 4 (3 reviews)

(3 Reviews)

(55 Publications)

Rabbit Polyclonal Synapsin I antibody. Suitable for WB and reacts with Rat samples. Cited in 55 publications. Immunogen corresponding to Native Full Length Protein corresponding to Cow SYN1.

View Alternative Names

Synapsin-1, Synapsin I, Syn1

1 Images

Supplier Data

Western blot - Anti-Synapsin I antibody - Synaptic Marker (AB8)

All lanes:

Western blot - Anti-Synapsin I antibody - Synaptic Marker (ab8)

All lanes:

Rat brain tissue lysate at 10 µg

Predicted band size: 74 kDa

Observed band size: 78 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Native Full Length Protein corresponding to Cow SYN1.

P17599

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.5 Constituents: 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.24% HEPES, 0.0001% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synapsin I also known as SYN1 plays an important role in synaptic function. It is a phosphoprotein with a molecular mass of approximately 78 kDa. Synapsin I is expressed mainly in the neurons of the central nervous system (CNS). It binds to synaptic vesicles and actin cytoskeleton which suggests that it functions in modulating neurotransmitter release at the presynaptic terminals. This modulation occurs as synapsin I undergoes phosphorylation which is critical for its activity.

Biological function summary

Synapsin I influences synaptic plasticity and is part of the synaptic vesicle trafficking complex. In its dephosphorylated state Synapsin I associates with synaptic vesicles anchoring them to the actin cytoskeleton. Upon phosphorylation Synapsin I changes conformation causing vesicles to mobilize. This activity supports the modulation of neurotransmitter release impacting learning and memory functions.

Pathways

Synapsin I participates significantly in the neurotransmitter release cycle and synaptic vesicle trafficking pathway. Protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulate its phosphorylation affecting how Synapsin I contributes to vesicle release. The phosphorylation of Synapsin I at sites such as serine 9 enables its interaction with other proteins like actin and spectrin facilitating vesicle movement.

Altered Synapsin I expression associates with neurological conditions like epilepsy and schizophrenia. In epilepsy dysregulation of Synapsin I phosphorylation processes can result in imbalanced neurotransmitter release potentially leading to seizures. Its connection to schizophrenia involves changes in synaptic plasticity which neurotransmitter systems such as dopamine and related proteins like alpha-synuclein also influence. Understanding these interactions can aid in developing therapeutic strategies.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Neuronal phosphoprotein that coats synaptic vesicles, and binds to the cytoskeleton. Acts as a regulator of synaptic vesicles trafficking, involved in the control of neurotransmitter release at the pre-synaptic terminal (PubMed : 11685225). Also involved in the regulation of axon outgrowth and synaptogenesis (By similarity). The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level (PubMed : 11867766).

See full target information Syn1

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Publications (55)

Recent publications for all applications. Explore the full list and refine your search

Molecular medicine (Cambridge, Mass.) 31:290 PubMed41013206

2025

Anti-P antibodies that impair memory perturb hippocampal glutamatergic receptor trafficking, synapse structure and microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole Díaz-Valdivia,Mariana Labarca,Claudio Retamal,Sofia Espinoza,Jaime Venegas,Alejandra Catenaccio,Adely de la Peña,Micaela Ricca,Claudia Jara,Daniela Cortés-Díaz,Angela Campos,Francisca Pérez-Molina,Francisca Barake,Bernardita Medel,Cristian Herrera-Cid,Fanny Guzman,Bredford Kerr,Manuel Varas-Godoy,Marcela Bravo-Zehnder,Loreto Massardo,Cheril Tapia-Rojas,Alfonso González

Molecular therapy : the journal of the American Society of Gene Therapy 33:421 PubMed39672159

2024

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

João Fonseca-Gomes,Tiago Costa-Coelho,Mafalda Ferreira-Manso,Sara Inteiro-Oliveira,Sandra H Vaz,Nuno Alemãn-Serrano,Henrique Atalaia-Barbacena,Leonor Ribeiro-Rodrigues,Rita M Ramalho,Rui Pinto,Hugo Vicente Miranda,Sara R Tanqueiro,Carolina de Almeida-Borlido,Maria João Ramalho,Catarina Miranda-Lourenço,Rita F Belo,Catarina B Ferreira,Vera Neves,Diogo M Rombo,Ricardo Viais,Juzoh Umemori,Ivo C Martins,André Jerónimo-Santos,António Caetano,Nuno Manso,Petra Mäkinen,Mikael Marttinen,Mari Takalo,Michael Bremang,Ian Pike,Annakaisa Haapasalo,Joana A Loureiro,Maria Carmo Pereira,Nuno C Santos,Tiago F Outeiro,Miguel A R B Castanho,Adelaide Fernandes,Mikko Hiltunen,Carlos B Duarte,Eero Castrén,Alexandre de Mendonça,Ana M Sebastião,Tiago M Rodrigues,Maria José Diógenes

Molecular therapy : the journal of the American Society of Gene Therapy 32:3372-3401 PubMed39205389

2024

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Neural regeneration research 17:1545-1555 PubMed34916440

2021

Electroacupuncture treatment improves motor function and neurological outcomes after cerebral ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Si-Si Li,Xu-Yun Hua,Mou-Xiong Zheng,Jia-Jia Wu,Zhen-Zhen Ma,Xiang-Xin Xing,Jie Ma,Chun-Lei Shan,Jian-Guang Xu

Cell reports 36:109419 PubMed34289368

2021

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia.

Applications

Unspecified application

Species

Unspecified reactive species

Sagar Gaikwad,Nicha Puangmalai,Alice Bittar,Mauro Montalbano,Stephanie Garcia,Salome McAllen,Nemil Bhatt,Minal Sonawane,Urmi Sengupta,Rakez Kayed

EMBO molecular medicine 13:e13591 PubMed34096686

2021

Pharmacological or genetic inhibition of iNOS prevents cachexia-mediated muscle wasting and its associated metabolism defects.

Applications

Unspecified application

Species

Unspecified reactive species

Jason Sadek,Derek T Hall,Bianca Colalillo,Amr Omer,Anne-Marie K Tremblay,Virginie Sanguin-Gendreau,William Muller,Sergio Di Marco,Marco Emilio Bianchi,Imed-Eddine Gallouzi

Nucleic acids research : PubMed33476385

2021

The metabolite methylglyoxal-mediated gene expression is associated with histone methylglyoxalation.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng-Wei Fu,Jian-Hui Li,Yu-Rui Feng,Xiao Yuan,Ying-Tang Lu

BMC biology 18:164 PubMed33158444

2020

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG.

Applications

Unspecified application

Species

Unspecified reactive species

Sofía Espinoza,Sebastián B Arredondo,Francisca Barake,Francisco Carvajal,Fernanda G Guerrero,Fabian Segovia-Miranda,David M Valenzuela,Ursula Wyneken,Alejandro Rojas-Fernández,Waldo Cerpa,Loreto Massardo,Lorena Varela-Nallar,Alfonso González

Neuron 107:667-683.e9 PubMed32616470

2020

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca Channels and Ca Entry.

Applications

Unspecified application

Species

Unspecified reactive species

Richard G Held,Changliang Liu,Kunpeng Ma,Austin M Ramsey,Tyler B Tarr,Giovanni De Nola,Shan Shan H Wang,Jiexin Wang,Arn M J M van den Maagdenberg,Toni Schneider,Jianyuan Sun,Thomas A Blanpied,Pascal S Kaeser

Aging 12:10951-10968 PubMed32518214

2020

Fibroblast growth factor 2 contributes to the effect of salidroside on dendritic and synaptic plasticity after cerebral ischemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Sisi Li,Yechen Lu,Daofang Ding,Zhenzhen Ma,Xiangxin Xing,Xuyun Hua,Jianguang Xu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

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Anti-Synapsin I antibody - Synaptic Marker

Western blot - Anti-Synapsin I antibody - Synaptic Marker (AB8)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (55)

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