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AB88563

Anti-Synapsin III antibody

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(1 Publication)

Mouse Polyclonal Synapsin III antibody. Carrier free. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Synapsin-3.

View Alternative Names

Synapsin-3, Synapsin III, SYN3

2 Images
Western blot - Anti-Synapsin III antibody (AB88563)
  • WB

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Western blot - Anti-Synapsin III antibody (AB88563)

All lanes:

Western blot - Anti-Synapsin III antibody (ab88563) at 1 µg/mL

All lanes:

rat brain tissue lysate at 50 µg

Predicted band size: 63 kDa

Observed band size: 55 kDa,70 kDa

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Western blot - Anti-Synapsin III antibody (AB88563)
  • WB

Unknown

Western blot - Anti-Synapsin III antibody (AB88563)

All lanes:

Western blot - Anti-Synapsin III antibody (ab88563) at 1 µg/mL

Lane 1:

Synapsin III transfected 293T cell lysate at 25 µg

Lane 2:

Non transfected 293T cell lysate at 25 µg

Predicted band size: 63 kDa

Observed band size: 70 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Synapsin-3.

O14994

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synapsin III also known as SYNIII is a phosphoprotein with an approximate mass of 64 kDa. Like other synapsins Synapsin III is mostly found in the brain where it plays an important role in synaptic function. It shows a widespread expression with notable abundance in the hippocampus and cerebral cortex. The protein associates with synaptic vesicles and neuronal membranes assisting in neurotransmitter release during neuronal communication.
Biological function summary

Synapsin III serves an important function in the regulation of neurotransmitter release and synaptic plasticity. It binds to synaptic vesicles and cytoskeletal elements organizing vesicle trafficking at the presynaptic terminal. Synapsin III is not part of a known larger protein complex but often works in concert with other synaptic proteins to influence synaptic vesicle dynamics. Its regulation of vesicle mobilization and docking highlights its function in fine-tuning neuronal communication.

Pathways

Synapsin III operates in nerve terminal signaling especially in pathways involving synaptic vesicle cycle. It contributes to processes in the synaptic vesicle cycle details of which comprise vesicle trafficking and neurotransmitter release. In these pathways it interacts with proteins such as Synapsin I and Synapsin II which share responsibilities in neurotransmitter regulation. These proteins together maintain synaptic activity under various physiological conditions.

Synapsin III has connections with neurological conditions such as schizophrenia and attention deficit hyperactivity disorder (ADHD). Studies indicate alterations in Synapsin III expression levels or function may contribute to synaptic impairments observed in these disorders. Additionally there is interaction with proteins like DISC1 (Disrupted in Schizophrenia 1) which further links Synapsin III to schizophrenia. Synapsin III sits in the broader context of synaptic proteins critical for normal cognitive functions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in the regulation of neurotransmitter release and synaptogenesis.
See full target information Synapsin-3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 12:e0186247 PubMed29190290

2017

Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse.

Applications

Unspecified application

Species

Unspecified reactive species

Mary F Rooney,Richard K Porter,Lisa M Katz,Emmeline W Hill
View all publications
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