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AB106460

Anti-Synaptogyrin 3 antibody

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(1 Publication)

Rabbit Polyclonal Synaptogyrin 3 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SYNGR3.

View Alternative Names

Synaptogyrin-3, SYNGR3

1 Images
Western blot - Anti-Synaptogyrin 3 antibody (AB106460)
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Western blot - Anti-Synaptogyrin 3 antibody (AB106460)

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Western blot - Anti-Synaptogyrin 3 antibody (ab106460) at 1 µg/mL

Lane 2:

Western blot - Anti-Synaptogyrin 3 antibody (ab106460) at 2 µg/mL

All lanes:

Mouse brain tissue lysate at 15 µg

Predicted band size: 24 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SYNGR3. The exact immunogen used to generate this antibody is proprietary information.

O43761

Specificity

ab106460 does not cross-react with other Synaptogyrin family members

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synaptogyrin 3 also known as SYNGR3 functions as a component of vesicular transport within the synaptic terminals. With a molecular mass of approximately 25 kDa this protein localizes mainly in the brain prominently within the presynaptic nerve terminals. It plays a role in neurotransmitter release by being involved in modulating synaptic vesicle exocytosis. SYNGR3 shares structural characteristics with other members of the synaptogyrin family marked by its transmembrane domains.
Biological function summary

SYNGR3 influences synaptic plasticity and neurotransmission efficiency. This protein acts in conjunction with synaptophysin part of a larger complex that regulates vesicle biogenesis and release dynamics. Its presence contributes to sustaining long-term potentiation and synaptic integrity rendering it important for memory and learning processes. Its activity is essential in maintaining effective communication between neurons across the synapses.

Pathways

SYNGR3 plays a significant role in the synaptic vesicle cycle pathway. This pathway involves recycling and mobilization of synaptic vesicles interacting with proteins such as synaptotagmin and VAMP2. Another key interaction involves the SNARE complex which is important for vesicle fusion and subsequent neurotransmitter release. SYNGR3 aids in aligning vesicles for efficient fusion impacting neuronal signaling pathways.

Dysfunction in SYNGR3 relates to neurological conditions such as schizophrenia and Alzheimer's disease. Abnormalities in SYNGR3 expression or function may disrupt synaptic transmission contributing to cognitive deficits seen in these disorders. There is also a connection between SYNGR3 and amyloid precursor protein (APP) suggesting disruptions in their interactions might exacerbate neurodegenerative processes. Understanding SYNGR3's role may provide insight into potential therapeutic targets for these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal.
See full target information SYNGR3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS chemical neuroscience 10:2033-2044 PubMed30284806

2018

Chronic Social Isolation Stress during Peri-Adolescence Alters Presynaptic Dopamine Terminal Dynamics via Augmentation in Accumbal Dopamine Availability.

Applications

Unspecified application

Species

Unspecified reactive species

Anushree N Karkhanis,Amy C Leach,Jordan T Yorgason,Ayse Uneri,Samuel Barth,Farr Niere,Nancy J Alexander,Jeffrey L Weiner,Brian A McCool,Kimberly F Raab-Graham,Mark J Ferris,Sara R Jones
View all publications
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