Rabbit Polyclonal Synaptophysin antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 11 publications.
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- NPJ Regenerative medicine 5:122020Neural stem cell delivery via porous collagen scaffolds promotes neuronal differentiation and locomotion recovery in spinal cord injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlexandra Kourgiantaki et. al.PubMed 32566251
- Nature communications 11:9132020MYCN amplification and ATRX mutations are incompatible in neuroblastoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMaged Zeineldin et. al.PubMed 32060267
- Journal of Alzheimer's disease : JAD 70:1025-10402019Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQini Gan,Hongbo Yao,Hana Na,Heather Ballance,Qiushan Tao,Lorene Leung,Hua Tian,Haihao Zhu,Benjamin Wolozin,Wei Qiao QiuPubMed 31306122
- Biochemical pharmacology 155:264-2742018Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential.Applications:Unspecified applicationReactive species:Unspecified reactive speciesN M Pathak et. al.PubMed 30028989
- Brain, behavior, and immunity 70:423-4342018Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPaul Denver et. al.PubMed 29604345
- The Journal of endocrinology 234:255-2672017Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPaul Millar et. al.PubMed 28611211
- Endocrinology 156:4592-6032015Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease.
- Neuropharmacology 76 Pt A:57-672013Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPaula L McClean,Christian HölscherPubMed 23973293
- Alzheimer's research & therapy 5:202013Neuroprotective effects of D-Ala(2)GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model.
- Journal of Alzheimer's disease : JAD 35:267-832013D-Ala2GIP facilitated synaptic plasticity and reduces plaque load in aged wild type mice and in an Alzheimer's disease mouse model.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
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Reactivity data
Select an application| ICC/IF | |
|---|---|
| Rat | Tested |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1 µg/mL | Notes - |
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Target data
Function
Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Alternative names
Synaptophysin, Major synaptic vesicle protein p38, SYP
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Rabbit Polyclonal Synaptophysin antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 11 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.6
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purification technique
- Affinity purification Immunogen
- Specificity
This antibody reacts with a hydrophilic peptide sequence of synaptophysin.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Synaptophysin also known as SYP is a glycoprotein approximately 38 kDa in size. It is expressed abundantly in the presynaptic vesicle membranes of neurons and in neuroendocrine cells. Synaptophysin serves as a marker for synaptic vesicles and neuroendocrine tumors. The protein plays a significant role in synaptic vesicle cycling processes engaging in the release and recycling of neurotransmitters.
- Biological function summary
Synaptophysin contributes to synaptic transmission and is engaged in the formation and maintenance of the synaptic vesicle pools. It is a part of the complex involved in neuronal communication and might interact with other vesicular proteins to ensure efficient neurotransmitter exchange. Researchers often utilize anti-Synaptophysin antibodies such as Alexa Fluor 647 labeled ones for visualization under confocal microscopy.
- Pathways
Synaptophysin operates within pathways involving neurotransmitter release and synaptic vesicle cycle. It connects to proteins like Synaptotagmin and SNAP-25 integral to the facilitation of synaptic transmission and exocytosis. These pathways ensure efficient signal conduction across neurons which is critical for normal nervous system functioning.
- Associated diseases and disorders
Synaptophysin shows a strong association with neurodegenerative diseases and certain cancers like neuroblastoma. Altered expression levels or dysfunction of Synaptophysin can serve as a diagnostic marker for these conditions. The protein is connected with proteins like Bcl-2 in neurodegenerative diseases affecting cell survival and apoptosis pathways.
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Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Immunocytochemistry/ Immunofluorescence - Anti-Synaptophysin antibody - Synaptic Marker (ab7837)
Synaptophysin Immunocytochemistry/ Immunofluorescence staining using rabbit Anti-Synaptophysin antibody
ICC/IF image of ab7837 stained PC12 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab7837, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.
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