AB34164

Anti-Syndecan-1 antibody [B-A38]

Name: Anti-Syndecan-1 antibody [B-A38] Mouse monoclonal (ab34164) | Abcam
Brand: Abcam Limited
SKU: AB34164
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

(10 Reviews)

(58 Publications)

Mouse Monoclonal Syndecan-1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 58 publications.

View Alternative Names

CD138, SDC, SDC1, Syndecan-1, SYND1

1 Images

Flow Cytometry - Anti-Syndecan-1 antibody [B-A38] (AB34164)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-Syndecan-1 antibody [B-A38] (AB34164)

Flow cytometry analysis of U266 cell line using ab34164

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

B-A38

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/en-us/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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Product details

This antibody stains all plasma cells and plasma cell lines. No staining of other leucocytes is seen in peripheral blood or bone marrow, although some ALL cell lines express the antigen weakly. Some staining of epithelial and endothelial cells may be seen in immunohistology.

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Properties and storage information

Form

Liquid

Purification technique

Ion exchange chromatography

Purification notes

Purified IgG prepared by ion exchange chromatography

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan-1 also known as CD138 is a transmembrane heparan sulfate proteoglycan with a molecular weight of approximately 30 to 80 kDa. The size variation arises from differences in its glycosaminoglycan chains. This protein resides predominantly on the surface of epithelial cells and plasma cells. Researchers commonly use the CD138 marker to identify these cells in biological samples. It plays a significant role in cell-cell and cell-matrix interactions acting as a co-receptor for a variety of growth factors cytokines and extracellular matrix proteins.

Biological function summary

Syndecan-1 participates in tissue repair inflammation and cell signaling ensuring epithelial integrity and communication. Syndecan-1 influences cell behavior by interacting with other components of the extracellular matrix and different membrane receptors. It is also involved in forming and regulating proteoglycan complexes at the cell surface. These complex interactions facilitate the modulation of cell proliferation migration and differentiation which are fundamental to maintaining tissue architecture and function.

Pathways

Syndecan-1 actively contributes to both the Wnt and FGF signaling pathways. Through its interaction with proteins such as miR-15 syndecan-1 modulates cellular responses essential for developmental processes and tissue homeostasis. The connection with these pathways allows syndecan-1 to integrate and relay extracellular signals impacting gene expression and cellular behavior. Its relationship with other proteins like A38 as a co-receptor emphasizes its role in finely tuning signaling cascades within cellular environments.

Syndecan-1 shows a connection to multiple myeloma and breast cancer. The overexpression of syndecan-1 in these conditions disrupts normal cellular functions and promotes tumorigenesis by aiding in the tumor cell's adhesion migration and invasion. Its interaction with proteins such as perCP further demonstrates its role in disease progression providing potential as a therapeutic target. These relationships make syndecan-1 an important focus for research in oncology and other fields of disease study.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

The protein expressed by the SDC1 gene is a cell surface proteoglycan with heparan sulfate and chondroitin sulfate, linking the cytoskeleton to the interstitial matrix. It regulates exosome biogenesis alongside SDCBP and PDCD6IP. This supplementary information is collated from multiple sources and compiled automatically.

See full target information SDC1

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Publications (58)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 30:180 PubMed40777564

2025

A rare dermatological manifestation of follicular spicules in a patient with multiple myeloma and end-stage renal disease on hemodialysis: A case report.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaobing Li,Xuemei Li,Qin Li,Qian Li,Yongsheng Liu,Li Zhang,Li Wang

International journal of molecular sciences 25: PubMed38674142

2024

Syndecans, Exostosins and Sulfotransferases as Potential Synovial Inflammation Moderators in Patients with Hip Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Matko Rošin,Nela Kelam,Ivana Jurić,Anita Racetin,Marin Ogorevc,Brieuc Corre,Davor Čarić,Natalija Filipović,Katarina Vukojević

American journal of physiology. Heart and circulatory physiology 325:H1337-H1353 PubMed37801046

2023

Neuraminidase inhibition improves endothelial function in diabetic mice.

Applications

Unspecified application

Species

Unspecified reactive species

Christopher A Foote,Francisco I Ramirez-Perez,James A Smith,Thaysa Ghiarone,Mariana Morales-Quinones,Neil J McMillan,Marc A Augenreich,Gavin Power,Katherine Burr,Annayya R Aroor,Shawn B Bender,Camila Manrique-Acevedo,Jaume Padilla,Luis A Martinez-Lemus

Methods in molecular biology (Clifton, N.J.) 2767:85-103 PubMed37402094

2023

Generation of 3D Trophoblast Organoids from Human Naïve Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Rowan M Karvas,Thorold W Theunissen

International journal of molecular sciences 24: PubMed36768381

2023

Commonalities and Disparities between Endometriosis and Chronic Endometritis: Therapeutic Potential of Novel Antibiotic Treatment Strategy against Ectopic Endometrium.

Applications

Unspecified application

Species

Unspecified reactive species

Kotaro Kitaya,Tadahiro Yasuo

Biomedicines 10: PubMed36551969

2022

Fibrosis-Associated Signaling Molecules Are Differentially Expressed in Palmar Connective Tissues of Patients with Carpal Tunnel Syndrome and Dupuytren's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Ivo Tripković,Marin Ogorevc,Dubravka Vuković,Mirna Saraga-Babić,Snježana Mardešić

Cell stem cell 29:810-825.e8 PubMed35523141

2022

Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.

Applications

Unspecified application

Species

Unspecified reactive species

Rowan M Karvas,Shafqat A Khan,Sonam Verma,Yan Yin,Devesha Kulkarni,Chen Dong,Kyoung-Mi Park,Brian Chew,Eshan Sane,Laura A Fischer,Deepak Kumar,Liang Ma,Adrianus C M Boon,Sabine Dietmann,Indira U Mysorekar,Thorold W Theunissen

Reproductive medicine and biology 21:e12421 PubMed35386364

2022

Occurrence of chronic endometritis in different types of human adenomyosis.

Applications

Unspecified application

Species

Unspecified reactive species

Khaleque N Khan,Akira Fujishita,Kanae Ogawa,Akemi Koshiba,Taisuke Mori,Kyoko Itoh,Masahiro Nakashima,Jo Kitawaki

Molecular medicine (Cambridge, Mass.) 28:18 PubMed35123388

2022

Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Ling,Lei Shen,Wei Zhang,DuoDuo Qu,Hongdong Wang,Bin Wang,Yong Liu,Jing Lu,Dalong Zhu,Yan Bi

Oncology reports 47: PubMed34958112

2021

Systematic characterization of the tumor microenvironment in Chinese patients with hepatocellular carcinoma highlights intratumoral B cells as a potential immunotherapy target.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Feng,Liguo Liu,Jing Li,Jia Huang,Jenny H Xie,Laurence Menard,Yanfen Shi,Xiaohong Zhao,Shan Xie,Wenjuan Zang,Haidong Tan,Zhiying Yang,Ling Ni

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Syndecan-1 antibody [B-A38]

Flow Cytometry - Anti-Syndecan-1 antibody [B-A38] (AB34164)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (58)

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