AB63932

Anti-Syndecan 3 antibody

(1 Review)

(7 Publications)

Rabbit Polyclonal Syndecan 3 antibody. Suitable for WB and reacts with Rat samples. Cited in 7 publications.

View Alternative Names

KIAA0468, SDC3, Syndecan-3, SYND3

1 Images

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Western blot - Anti-Syndecan 3 antibody (AB63932)

All lanes:

Western blot - Anti-Syndecan 3 antibody (ab63932) at 1 µg/mL

All lanes:

Rat kidney tissue lysate at 30 µg

Predicted band size: 45 kDa

Observed band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat

Applications

applications

Immunogen

Synthetic Peptide within Human SDC3. The exact immunogen used to generate this antibody is proprietary information.

O75056

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-4 µg/mL", "WB-species-notes": "<p></p>" } } }

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Product details

This product is manufactured by BioVision, an Abcam company and was previously called 3824 Syndecan-3 Antibody. 3824-100 is the same size as the 100 µg size of ab63932.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan 3 also known as N-syndecan is a heparan sulfate proteoglycan with a molecular mass of around 120-150 kDa. It has a core protein containing three heparan sulfate chains essential for its function. Expressed mainly in the nervous system Syndecan 3 shows significant concentration in neurons and glial cells. This proteoglycan plays an important role in cell-cell and cell-matrix interactions and contributes to neural developmental processes.

Biological function summary

Syndecan 3 modulates cellular behaviors including proliferation differentiation and migration. It functions as a co-receptor for various growth factors and adhesion molecules. This interaction facilitates signaling pathways that influence neural structure and function. Syndecan 3 forms complexes with other cell surface molecules which enhance its ability to mediate cellular responses. These interactions are essential for the development and maintenance of the nervous system.

Pathways

Syndecan 3 interacts within important signaling cascades such as the Wnt and fibroblast growth factor (FGF) pathways. The Wnt pathway involves the regulation of gene expression critical for cellular processes while FGF pathways direct cell division and differentiation. Syndecan 3's interaction with proteins like FGF receptors highlights its role in these pathways. It aids in modulating the activity of related proteins coordinating integrative signals that ensure proper neuronal development.

Syndecan 3 relates to neurodegenerative conditions like Alzheimer's Disease and developmental disorders such as autism. In Alzheimer's Disease its association with amyloid beta precursor protein (APP) suggests a role in amyloid plaque formation. In autism changes in the expression of Syndecan 3 may influence neural connectivity and communication. These interactions emphasize the importance of Syndecan 3 in maintaining neuronal integrity and highlight its potential as a therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.

See full target information SDC3

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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Journal of cardiovascular pharmacology 79:e103-e115 PubMed34654784

2021

A Role for Peroxisome Proliferator-Activated Receptor Gamma Agonists in Counteracting the Degeneration of Cardiovascular Grafts.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Kathrin Assmann,Daniel Goschmer,Yukiharu Sugimura,Agunda Chekhoeva,Mareike Barth,Alexander Assmann,Artur Lichtenberg,Payam Akhyari

Glia 66:801-812 PubMed29282769

2017

Glial M6B stabilizes the axonal membrane at peripheral nodes of Ranvier.

Applications

Unspecified application

Species

Unspecified reactive species

Marie L Bang,Anya Vainshtein,Hyun-Jeong Yang,Yael Eshed-Eisenbach,Jerome Devaux,Hauke B Werner,Elior Peles

Investigative ophthalmology & visual science 56:3004-14 PubMed26024086

2015

Loss of corneal epithelial heparan sulfate leads to corneal degeneration and impaired wound healing.

Applications

Unspecified application

Species

Unspecified reactive species

Vivien Jane Coulson-Thomas,Shao-Hsuan Chang,Lung-Kun Yeh,Yvette May Coulson-Thomas,Yu Yamaguchi,Jeffrey Esko,Chia-Yang Liu,Winston Kao

PloS one 10:e0117404 PubMed25617766

2015

Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mari Tinholt,Benedicte Stavik,William Louch,Cathrine Rein Carlson,Marit Sletten,Wolfram Ruf,Grethe Skretting,Per Morten Sandset,Nina Iversen

The Journal of neuroscience : the official journal of the Society for Neuroscience 34:14820-6 PubMed25378149

2014

Caspr and caspr2 are required for both radial and longitudinal organization of myelinated axons.

Applications

Unspecified application

Species

Mouse

Aaron Gordon,Konstantin Adamsky,Anya Vainshtein,Shahar Frechter,Jeffrey L Dupree,Jack Rosenbluth,Elior Peles

The Journal of biological chemistry 289:25211-26 PubMed25053416

2014

Heparan sulfate regulates hair follicle and sebaceous gland morphogenesis and homeostasis.

Applications

IHC-FoFr

Species

Mouse

Vivien Jane Coulson-Thomas,Tarsis Ferreira Gesteira,Jeffrey Esko,Winston Kao

The American journal of pathology 180:693-702 PubMed22138583

2011

Placental syndecan expression is altered in human idiopathic fetal growth restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Amy Chui,Nurul Zainuddin,Gayathri Rajaraman,Padma Murthi,Shaun P Brennecke,Vera Ignjatovic,Paul T Monagle,Joanne M Said

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Syndecan 3 antibody

Western blot - Anti-Syndecan 3 antibody (AB63932)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (7)

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