AB191308

Anti-Syndecan 3 antibody - N-terminal

Name: Anti-Syndecan 3 antibody - N-terminal (ab191308) | Abcam
Brand: Abcam Limited
SKU: AB191308

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(3 Publications)

Rabbit Polyclonal Syndecan 3 antibody. N-terminal. Suitable for IHC-P, WB and reacts with Rat, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Mouse Sdc3 aa 1-100.

View Alternative Names

KIAA0468, SDC3, Syndecan-3, SYND3

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan 3 antibody - N-terminal (AB191308)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan 3 antibody - N-terminal (AB191308)

Immunohistochemical analysis of paraffin-embedded Human placenta tissue labeling Syndecan 3 with ab191308 at 1 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan 3 antibody - N-terminal (AB191308)

Immunohistochemical analysis of paraffin-embedded Rat brain tissue labeling Syndecan 3 with ab191308 at 1 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Mouse Sdc3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q64519

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan 3 also known as N-syndecan is a heparan sulfate proteoglycan with a molecular mass of around 120-150 kDa. It has a core protein containing three heparan sulfate chains essential for its function. Expressed mainly in the nervous system Syndecan 3 shows significant concentration in neurons and glial cells. This proteoglycan plays an important role in cell-cell and cell-matrix interactions and contributes to neural developmental processes.

Biological function summary

Syndecan 3 modulates cellular behaviors including proliferation differentiation and migration. It functions as a co-receptor for various growth factors and adhesion molecules. This interaction facilitates signaling pathways that influence neural structure and function. Syndecan 3 forms complexes with other cell surface molecules which enhance its ability to mediate cellular responses. These interactions are essential for the development and maintenance of the nervous system.

Pathways

Syndecan 3 interacts within important signaling cascades such as the Wnt and fibroblast growth factor (FGF) pathways. The Wnt pathway involves the regulation of gene expression critical for cellular processes while FGF pathways direct cell division and differentiation. Syndecan 3's interaction with proteins like FGF receptors highlights its role in these pathways. It aids in modulating the activity of related proteins coordinating integrative signals that ensure proper neuronal development.

Syndecan 3 relates to neurodegenerative conditions like Alzheimer's Disease and developmental disorders such as autism. In Alzheimer's Disease its association with amyloid beta precursor protein (APP) suggests a role in amyloid plaque formation. In autism changes in the expression of Syndecan 3 may influence neural connectivity and communication. These interactions emphasize the importance of Syndecan 3 in maintaining neuronal integrity and highlight its potential as a therapeutic target.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.

See full target information SDC3

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 22: PubMed34445387

2021

Syndecan Family Gene and Protein Expression and Their Prognostic Values for Prostate Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Nilton José Santos,Caroline Nascimento Barquilha,Isabela Correa Barbosa,Rodrigo Tavares Macedo,Flávio Oliveira Lima,Luis Antônio Justulin,Guilherme Oliveira Barbosa,Hernandes F Carvalho,Sérgio Luis Felisbino

Aging 12: PubMed33495414

2021

Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Shushi Huang,Shengban You,Jinfu Qian,Chengyi Dai,Siyuan Shen,Jun Wang,Weijian Huang,Guang Liang,Gaojun Wu

EBioMedicine 27:71-85 PubMed29248508

2017

Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Hsiaoyun Lin,Rieko Muramatsu,Noriko Maedera,Hiroto Tsunematsu,Machika Hamaguchi,Yoshihisa Koyama,Mariko Kuroda,Kenji Ono,Makoto Sawada,Toshihide Yamashita

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Syndecan 3 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan 3 antibody - N-terminal (AB191308)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Syndecan 3 antibody - N-terminal (AB191308)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise