Anti-Syntaxin 16 antibody [EPR9156]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Syntaxin 16 also known as STX16 is a member of the syntaxin family that has a central role in vesicular trafficking. This protein weighs approximately 37 kDa and is expressed in various tissues with notable presence in the brain and kidney. Syntaxin 16 is an integral membrane protein located mainly in the Golgi apparatus. It interacts with other SNARE proteins to mediate the fusion of vesicles with target membranes facilitating the movement of proteins and lipids within cells.

Biological function summary

Syntaxin 16 is involved in the proper distribution of proteins across cellular compartments. It is a component of the SNARE complex which is essential for membrane fusion events. Syntaxin 16 plays a significant role in endosomal trafficking where it helps in sorting and recycling of membrane proteins. The protein's function ensures that nutrients and signaling molecules are correctly transported and that cellular homeostasis is maintained.

Pathways

Syntaxin 16 is involved in essential intracellular trafficking pathways. One such pathway is the endosomal-lysosomal pathway regulating the recycling and degradation of cellular components. It also plays a part in the transport between the trans-Golgi network and endosomes where it works closely with proteins like VAMP4 and Vti1a. These interactions ensure the directional flow of vesicles and the maintenance of cellular organization.

Associated diseases and disorders

Syntaxin 16 shows relevance to conditions affecting neurological and renal systems. Syntaxin 16 has been implicated in some neurodegenerative diseases suggesting disruptions in vesicular trafficking may contribute to pathogenesis. Furthermore altered expression or function of Syntaxin 16 affects renal function possibly connecting with proteins like VAMP2 which can influence kidney-related disorders. Understanding Syntaxin 16's role offers valuable insights into the cellular mechanisms underlying these diseases.