AB233104

Anti-T Plastin/PLS3 antibody

Name: Anti-T Plastin/PLS3 antibody (ab233104) | Abcam
Brand: Abcam Limited
SKU: AB233104
Price: 510 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal T Plastin/PLS3 antibody. Suitable for WB, IHC-P and reacts with Mouse, Recombinant fragment - Human, Pig, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLS3 aa 350 to C-terminus.

View Alternative Names

Plastin-3, T-fimbrin, T-plastin, PLS3

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Formalin-fixed, paraffin-embedded human prostate cancer tissue stained for T Plastin/PLS3 using ab233104 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Formalin-fixed, paraffin-embedded human rectum cancer tissue stained for T Plastin/PLS3 using ab233104 at 10 μg/ml in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for T Plastin/PLS3 using ab233104 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-T Plastin/PLS3 antibody (AB233104)

All lanes:

Western blot - Anti-T Plastin/PLS3 antibody (ab233104) at 2 µg/mL

All lanes:

Recombinant human T Plastin/PLS3 protein

Predicted band size: 71 kDa

false

Supplier Data

Western blot - Anti-T Plastin/PLS3 antibody (AB233104)

All lanes:

Western blot - Anti-T Plastin/PLS3 antibody (ab233104) at 2 µg/mL

Lane 1:

Pig liver tissue

Lane 2:

Pig heart tissue

Lane 3:

Mouse liver tissue

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit at 1/2000 dilution

Predicted band size: 71 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human, Pig

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PLS3 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P13797

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant fragment - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The T Plastin also known as PLS3 is a protein with a mass of around 70 kDa. This protein belongs to the plastin family and another popular alias is plastine. T Plastin participates in cellular mechanics by bundling actin filaments which is essential for maintaining cell structure and motility. It occurs in various tissues but is highly expressed in the intestines testis and other cells with rapid movement needs like immune cells. Its presence supports functions needing dynamic rearrangement of the cytoskeleton.

Biological function summary

T Plastin plays significant roles in several cellular activities. It stabilizes the actin cytoskeleton which impacts cell division signal transduction and cellular interactions. T Plastin is not part of a multi-protein complex but works closely with actin and other actin-binding proteins to regulate cytoskeletal organization. By supporting these functions T Plastin indirectly influences cell shape and intracellular transport mechanisms.

Pathways

T Plastin integrates into the actin dynamics pathways important for cytoskeletal reorganization. It works alongside proteins such as cofilin and profilin which also regulate actin dynamics. Another important pathway includes wound healing where T Plastin's actin-bundling function assists in cell migration and tissue regeneration. In these pathways its role ensures efficient cellular responses to environmental changes.

Defects in T Plastin have been linked to osteoporosis and some forms of cancers. In osteoporosis improper expression of T Plastin affects bone density regulation partly due to its influence on osteoclast function. Cancers such as colorectal cancer exhibit altered T Plastin levels which may impact metastasis due to changes in cell motility. In these contexts T Plastin's interaction with other proteins like integrins highlights its importance in controlling cell adhesion and migration associated with disease progress.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Actin-bundling protein.

See full target information PLS3

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed41009430

2025

In Vivo Immune Cell Responses and Long-Term Effects of Cold Atmospheric Plasma in the Upper Respiratory Tract.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Arndt,Petra Unger,Lisa Gebhardt,Robert Schober,Mark Berneburg,Sigrid Karrer

eLife 12: PubMed37083757

2023

Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant mutation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Hu,Bingna Zhou,Xiaoyun Lin,Qian Zhang,Feifei Guan,Lei Sun,Jiayi Liu,Ou Wang,Yan Jiang,Wei-Bo Xia,Xiaoping Xing,Mei Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-T Plastin/PLS3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T Plastin/PLS3 antibody (AB233104)

Western blot - Anti-T Plastin/PLS3 antibody (AB233104)

Western blot - Anti-T Plastin/PLS3 antibody (AB233104)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise