Rabbit Polyclonal T1R3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R3.
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Publications
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- Frontiers in nutrition 8:7208892021Drinking Non-nutritive Sweetness Solution of Sodium Saccharin or Rebaudioside a for Guinea Pigs: Influence on Histologic Change and Expression of Sweet Taste Receptors in Testis and Epididymis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing Shen,Junrong LiPubMed 34422887
- Animals : an open access journal from MDPI 11:2021Longitudinal Expression of Testicular from Prepuberty to Sexual Maturity in Congjiang Xiang Pigs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing Gong,Weiyong Wang,Houqiang Xu,Yi Yang,Xiang Chen,Lijie Meng,Yongjian Xu,Ziqing Li,Sufang Wan,Qi MuPubMed 33567555
- Animal science journal = Nihon chikusan Gakkaiho 91:e133482020Influences of non-nutritive sweeteners on ovarian and uterine expression of T1R2 and T1R3 in peripubertal female guinea pigs.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJunrong Li,Ting Shen,Fangxiong Shi,Yan FuPubMed 32219957
- Journal of agricultural and food chemistry 67:6809-68182019Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Tian et. al.PubMed 31134808
- Food & function 10:3356-33672019Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin Tian,Jinghui Heng,Hanqing Song,Yufeng Zhang,Fang Chen,Wutai Guan,Shihai ZhangPubMed 31098606
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TAS1R3. The exact immunogen used to generate this antibody is proprietary information. Database link Q7RTX0
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Baboon | Predicted |
| Chimpanzee | Predicted |
| Gorilla | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10.00000-20.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Baboon, Gorilla | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
Alternative names
T1R3, TR3, TAS1R3, Taste receptor type 1 member 3, Sweet taste receptor T1R3
Recommended products
Rabbit Polyclonal T1R3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R3.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TAS1R3. The exact immunogen used to generate this antibody is proprietary information. Database link Q7RTX0
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
T1R3 also known as TAS1R3 functions as a taste receptor. Weighing around 90kDa T1R3 is part of the G protein-coupled receptor family. It is largely expressed in the taste buds on the tongue and some extraoral tissues. T1R3 partners with TAS1R1 or TAS1R2 to detect umami and sweet taste respectively. This protein is critical in the detection and signaling of taste perceptions in the gustatory pathways.
- Biological function summary
T1R3 plays a role in nutrient sensing and metabolic regulation. As part of a receptor complex T1R3 partners with TAS1R2 to form a sweet taste receptor and pairs with TAS1R1 to form an umami receptor. This pairing occurs at the cell surface in the taste buds and is vital for the recognition of specific ligands like amino acids and sugars. T1R3's ability to sense nutrients impacts digestive processes and energy balance.
- Pathways
T1R3 involvement extends to signaling pathways related to taste signaling and energy homeostasis. T1R3 activates taste GPCR pathways which contribute to neurotransmitter release in taste perceptions. It connects to the phosphatidylinositol signaling system pathway impacting cellular processes through interaction with proteins like PLCβ2. T1R3 also interfaces with cellular mechanisms influenced by serotonin and glutamate receptors.
- Associated diseases and disorders
T1R3 has a connection to metabolic diseases including obesity and diabetes. It influences glucose metabolism and energy intake linking it to these conditions. T1R3 has interactions with other proteins such as leptin which is involved in body weight regulation. Impairment or alterations in T1R3 function can correlate with dietary-related disorders impacting disease progression through metabolic pathways.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T1R3 antibody (ab150525)
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tongue, squamous epithelium labelling T1R3 with ab150525 at 17 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-T1R3 antibody (ab150525)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skin tissue labelling T1R3 with ab150525. Heat-induced antigen retrieval was performed.
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