Rabbit Polyclonal TAAR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAAR1.
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Publications
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- Histochemistry and cell biology 152:155-1662019TAAR1 levels and sub-cellular distribution are cell line but not breast cancer subtype specific.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMallory S Pitts et. al.PubMed 31111198
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human TAAR1. The exact immunogen used to generate this antibody is proprietary information. Database link Q96RJ0
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Chimpanzee | Predicted |
| Elephant | Predicted |
| Gorilla | Predicted |
| Monkey | Predicted |
| Orangutan | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 6.00000-15.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Chimpanzee, Monkey, Gorilla, Orangutan, Elephant | Dilution info - | Notes - |
Target data
Function
Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:11459929, PubMed:11723224, PubMed:15718104, PubMed:31399635, PubMed:36100653, PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (PubMed:31399635, PubMed:37935376, PubMed:37935377). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (PubMed:11459929, PubMed:11723224). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (PubMed:37935376, PubMed:37935377, PubMed:37963465, PubMed:38168118). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:31399635, PubMed:37935376, PubMed:37963465). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (PubMed:31399635, PubMed:37935376, PubMed:37963465). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:37935376, PubMed:37963465). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed:37935376, PubMed:37963465). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (PubMed:37935376, PubMed:37963465). Amphetamine-binding is coupled with G(s)- or G(12)/G(13) G alpha protein subtypes (PubMed:31399635).
Alternative names
TA1, TAR1, TRAR1, TAAR1, Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1
Recommended products
Rabbit Polyclonal TAAR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAAR1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human TAAR1. The exact immunogen used to generate this antibody is proprietary information. Database link Q96RJ0
- Purification technique
- Affinity purification Immunogen
- Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1 month
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TAAR1 also known as Trace Amine-Associated Receptor 1 is a G-protein-coupled receptor primarily involved in the modulation of monoaminergic systems in the brain. It has an approximate molecular mass of 37 kDa. This receptor is expressed largely in the central nervous system particularly in regions such as the prefrontal cortex amygdala and hippocampus but also found in some peripheral tissues like the pancreas. TAAR1 is responsive to trace amines which are endogenous compounds structurally related to monoamine neurotransmitters.
- Biological function summary
TAAR1 influences monoaminergic activity. It plays a critical role in regulating the release and reuptake of neurotransmitters like dopamine and serotonin. It does not form part of a larger receptor complex but instead exerts its influence by interacting with proteins associated with neurotransmitter release management. TAAR1's activation produces various responses depending on the cell type and neurological context impacting mood and cognition processes.
- Pathways
TAAR1 signaling integrates into dopaminergic and serotonergic pathways. It modulates the activity of these pathways by altering the concentration of neurotransmitters through interacting with dopaminergic D2 receptors and serotonin transporters. This receptor operates within these pathways by providing feedback control influencing neurotransmitter dynamics critically involved in mood regulation and behavior expression.
- Associated diseases and disorders
TAAR1 connects closely to schizophrenia and depression. Studies associate its functional activity with altered monoamine levels seen in these conditions. In schizophrenia TAAR1 has connections with dopamine dysregulation with proteins such as the D2 receptor heavily implicated in pathophysiology. In depression its modulation of serotonin transporter function may impact therapeutic outcomes. Understanding TAAR1's role in these disorders helps guide the development of novel targeted therapies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAAR1 antibody (ab150646)
Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain (neurons) tissue, labeling TAAR1 with ab150646 at 15 μg/ml.
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