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AB150646

Anti-TAAR1 antibody

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(2 Publications)

Rabbit Polyclonal TAAR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TAAR1.

View Alternative Names

TA1, TAR1, TRAR1, TAAR1, Trace amine-associated receptor 1, TaR-1, Trace amine receptor 1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAAR1 antibody (AB150646)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAAR1 antibody (AB150646)

Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain (neurons) tissue, labeling TAAR1 with ab150646 at 15 μg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human TAAR1. The exact immunogen used to generate this antibody is proprietary information.

Q96RJ0

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "6-15 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1 month
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAAR1 also known as Trace Amine-Associated Receptor 1 is a G-protein-coupled receptor primarily involved in the modulation of monoaminergic systems in the brain. It has an approximate molecular mass of 37 kDa. This receptor is expressed largely in the central nervous system particularly in regions such as the prefrontal cortex amygdala and hippocampus but also found in some peripheral tissues like the pancreas. TAAR1 is responsive to trace amines which are endogenous compounds structurally related to monoamine neurotransmitters.
Biological function summary

TAAR1 influences monoaminergic activity. It plays a critical role in regulating the release and reuptake of neurotransmitters like dopamine and serotonin. It does not form part of a larger receptor complex but instead exerts its influence by interacting with proteins associated with neurotransmitter release management. TAAR1's activation produces various responses depending on the cell type and neurological context impacting mood and cognition processes.

Pathways

TAAR1 signaling integrates into dopaminergic and serotonergic pathways. It modulates the activity of these pathways by altering the concentration of neurotransmitters through interacting with dopaminergic D2 receptors and serotonin transporters. This receptor operates within these pathways by providing feedback control influencing neurotransmitter dynamics critically involved in mood regulation and behavior expression.

TAAR1 connects closely to schizophrenia and depression. Studies associate its functional activity with altered monoamine levels seen in these conditions. In schizophrenia TAAR1 has connections with dopamine dysregulation with proteins such as the D2 receptor heavily implicated in pathophysiology. In depression its modulation of serotonin transporter function may impact therapeutic outcomes. Understanding TAAR1's role in these disorders helps guide the development of novel targeted therapies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Intracellular G-protein coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed : 11459929, PubMed : 11723224, PubMed : 15718104, PubMed : 31399635, PubMed : 36100653, PubMed : 37935376, PubMed : 37935377, PubMed : 37963465, PubMed : 38168118). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (PubMed : 31399635, PubMed : 37935376, PubMed : 37935377). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (PubMed : 11459929, PubMed : 11723224). Expressed in both the central and peripheral nervous system : TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (PubMed : 37935376, PubMed : 37935377, PubMed : 37963465, PubMed : 38168118). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed : 31399635, PubMed : 37935376, PubMed : 37963465). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (PubMed : 31399635, PubMed : 37935376, PubMed : 37963465). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (PubMed : 37935376, PubMed : 37963465). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed : 37935376, PubMed : 37963465). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed : 37935376, PubMed : 37963465). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (PubMed : 37935376, PubMed : 37963465). Amphetamine-binding is coupled with G(s)- or G(12)/G(13) G alpha protein subtypes (PubMed : 31399635).
See full target information TAAR1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1620931 PubMed40873572

2025

Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Jiale Wang,Huan Li,Mingrui Shi,Chenghao Ren,Wu Wei,Qi Zhao,Xinxin He,Zihui Yang,Jianhua Wei,Xinjie Yang

Histochemistry and cell biology 152:155-166 PubMed31111198

2019

TAAR1 levels and sub-cellular distribution are cell line but not breast cancer subtype specific.

Applications

Unspecified application

Species

Unspecified reactive species

Mallory S Pitts,Josh N McShane,Marius C Hoener,Sherri L Christian,Mark D Berry
View all publications
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