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Rabbit Polyclonal TAAR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAAR1.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human TAAR1. The exact immunogen used to generate this antibody is proprietary information. Database link Q96RJ0
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Chimpanzee
Predicted
Elephant
Predicted
Gorilla
Predicted
Monkey
Predicted
Orangutan
Predicted

Tested
Tested

Species

Human

Dilution info

6.00000-15.00000 µg/mL

Notes

Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.

Predicted
Predicted

Species

Chimpanzee, Monkey, Gorilla, Orangutan, Elephant

Dilution info

-

Notes

-

Target data

Function

Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase.

Alternative names

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Rabbit Polyclonal TAAR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TAAR1.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen

Synthetic Peptide within Human TAAR1. The exact immunogen used to generate this antibody is proprietary information.Database link Q96RJ0

Purification technique

Affinity purification Immunogen

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1 month

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological summary

TAAR1 influences monoaminergic activity. It plays a critical role in regulating the release and reuptake of neurotransmitters like dopamine and serotonin. It does not form part of a larger receptor complex but instead exerts its influence by interacting with proteins associated with neurotransmitter release management. TAAR1's activation produces various responses depending on the cell type and neurological context impacting mood and cognition processes.

Mechanical summary

TAAR1 also known as Trace Amine-Associated Receptor 1 is a G-protein-coupled receptor primarily involved in the modulation of monoaminergic systems in the brain. It has an approximate molecular mass of 37 kDa. This receptor is expressed largely in the central nervous system particularly in regions such as the prefrontal cortex amygdala and hippocampus but also found in some peripheral tissues like the pancreas. TAAR1 is responsive to trace amines which are endogenous compounds structurally related to monoamine neurotransmitters.

Pathway

TAAR1 signaling integrates into dopaminergic and serotonergic pathways. It modulates the activity of these pathways by altering the concentration of neurotransmitters through interacting with dopaminergic D2 receptors and serotonin transporters. This receptor operates within these pathways by providing feedback control influencing neurotransmitter dynamics critically involved in mood regulation and behavior expression.

Disease

TAAR1 connects closely to schizophrenia and depression. Studies associate its functional activity with altered monoamine levels seen in these conditions. In schizophrenia TAAR1 has connections with dopamine dysregulation with proteins such as the D2 receptor heavily implicated in pathophysiology. In depression its modulation of serotonin transporter function may impact therapeutic outcomes. Understanding TAAR1's role in these disorders helps guide the development of novel targeted therapies.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAAR1 antibody (ab150646), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAAR1 antibody (ab150646)

    Immunohistochemical analysis of formalin fixed, paraffin embedded Human brain (neurons) tissue, labeling TAAR1 with ab150646 at 15 μg/ml.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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