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AB264308

Anti-TAB2 antibody

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Rabbit Polyclonal TAB2 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human TAB2 aa 300-350.

View Alternative Names

KIAA0733, MAP3K7IP2, TAB2, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2

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Immunoprecipitation - Anti-TAB2 antibody (AB264308)
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Supplier Data

Immunoprecipitation - Anti-TAB2 antibody (AB264308)

TAB2 was immunoprecipitated from 1mg of HeLa (Human epithelial cell line from cervix adenocarcinoma) whole cell lysate with ab264308 at 3 μg/mg lysate. Western blot was performed from the immunoprecipitate using a different TAB2 antibody at 1 μg/ml.

Lane 1 : ab264308 IP in HeLa whole cell lysate.
Lane 2 : Control IgG.

Exposure time : 30 secs.

All lanes:

Immunoprecipitation - Anti-TAB2 antibody (ab264308)

Predicted band size: 76 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human TAB2 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NYJ8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAB2 also known as TGF-beta-activated kinase 1 binding protein 2 or MAP3K7IP2 is an adapter protein with a mass of approximately 71 kDa. It plays a mechanical role in the nuclear and cytoplasmic compartments acting as a critical component in signaling pathways. Its expression is notable in various tissues including the heart placenta and skeletal muscle. TAB2 mainly functions by interacting with kinases to relay and amplify signals in the cell especially those related to inflammation and stress responses.
Biological function summary

TAB2 maintains a significant position in cellular signaling as part of larger protein complexes. It associates with TAK1 (transforming growth factor-beta-activated kinase 1) to regulate NF-kappaB and MAPK pathways. Through these interactions TAB2 helps cells respond to environmental signals mediating transcriptional responses necessary for adaptation and defense mechanisms. In particular TAB2's role in these complexes underlines its importance in immune response modulation and cellular homeostasis.

Pathways

TAB2 is deeply involved in both the NF-kappaB and MAPK signaling pathways where it cooperates intimately with proteins such as TAK1 and TAB1. These pathways are essential for gene expression regulation in response to pro-inflammatory signals. TAB2 facilitates the activation of IKK complex within the NF-kappaB pathway and JNK in the MAPK pathway. By influencing these pathways TAB2 governs important cellular processes like apoptosis proliferation and differentiation.

TAB2's dysfunction has strong connections with inflammatory and cardiovascular diseases. Its interaction with TAK1 and other proteins can lead to aberrant signaling therefore associating TAB2 with conditions such as rheumatoid arthritis and cardiac hypertrophy. In cardiomyopathies for instance disturbances in TAB2's function can affect signal transduction significantly impacting cardiac muscle structure and function. Understanding TAB2 and its intricate network of protein interactions aids in uncovering therapeutic targets for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed : 10882101, PubMed : 11460167, PubMed : 15327770, PubMed : 22158122, PubMed : 33184450, PubMed : 36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed : 10882101, PubMed : 11460167, PubMed : 15327770, PubMed : 22158122). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2 : this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed : 15327770, PubMed : 18079694, PubMed : 22158122). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed : 20493459).
See full target information TAB2
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