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AB313864

Anti-TAB2 antibody [HL1712] - BSA and Azide free

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Rabbit Recombinant Monoclonal TAB2 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human TAB2.

View Alternative Names

KIAA0733, MAP3K7IP2, TAB2, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2, Kiaa0733, Map3k7ip2, Tab2, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TGF-beta-activated kinase 1-binding protein 2, TAB-2

2 Images
Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (AB313864)
  • WB

Supplier Data

Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (AB313864)

All lanes:

Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (ab313864) at 1/1000 dilution

Lane 1:

Raji (Human Burkitt's lymphoma cell line) whole cell extract at 30 µg

Lane 2:

A20 (Mouse reticulum sarcoma cell line) whole cell extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 76 kDa

false

Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (AB313864)
  • WB

Supplier Data

Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (AB313864)

All lanes:

Western blot - Anti-TAB2 antibody [HL1712] - BSA and Azide free (ab313864) at 1/1000 dilution

All lanes:

A20 (Mouse reticulum sarcoma cell line) whole cell extract at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 76 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL1712

Isotype

IgG

Carrier free

Yes

Reacts with

Human, Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human TAB2.

Q9NYJ8

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Secondary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }
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Product details

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAB2 also known as TGF-beta-activated kinase 1 binding protein 2 or MAP3K7IP2 is an adapter protein with a mass of approximately 71 kDa. It plays a mechanical role in the nuclear and cytoplasmic compartments acting as a critical component in signaling pathways. Its expression is notable in various tissues including the heart placenta and skeletal muscle. TAB2 mainly functions by interacting with kinases to relay and amplify signals in the cell especially those related to inflammation and stress responses.
Biological function summary

TAB2 maintains a significant position in cellular signaling as part of larger protein complexes. It associates with TAK1 (transforming growth factor-beta-activated kinase 1) to regulate NF-kappaB and MAPK pathways. Through these interactions TAB2 helps cells respond to environmental signals mediating transcriptional responses necessary for adaptation and defense mechanisms. In particular TAB2's role in these complexes underlines its importance in immune response modulation and cellular homeostasis.

Pathways

TAB2 is deeply involved in both the NF-kappaB and MAPK signaling pathways where it cooperates intimately with proteins such as TAK1 and TAB1. These pathways are essential for gene expression regulation in response to pro-inflammatory signals. TAB2 facilitates the activation of IKK complex within the NF-kappaB pathway and JNK in the MAPK pathway. By influencing these pathways TAB2 governs important cellular processes like apoptosis proliferation and differentiation.

TAB2's dysfunction has strong connections with inflammatory and cardiovascular diseases. Its interaction with TAK1 and other proteins can lead to aberrant signaling therefore associating TAB2 with conditions such as rheumatoid arthritis and cardiac hypertrophy. In cardiomyopathies for instance disturbances in TAB2's function can affect signal transduction significantly impacting cardiac muscle structure and function. Understanding TAB2 and its intricate network of protein interactions aids in uncovering therapeutic targets for these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed : 10882101, PubMed : 11460167, PubMed : 15327770, PubMed : 22158122, PubMed : 27746020, PubMed : 33184450, PubMed : 36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed : 10882101, PubMed : 11460167, PubMed : 15327770, PubMed : 22158122, PubMed : 27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2 : this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed : 15327770, PubMed : 18079694, PubMed : 22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed : 27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed : 20493459).
See full target information TAB2

Additional targets

Tab2
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Product promise

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