Anti-TAB3 antibody [EPR5965]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

TAB3 also known as TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 is an essential protein that modulates important cellular processes. It has a molecular mass of approximately 90 kDa. The protein functions mechanically to activate downstream signaling pathways acting as an adapter molecule. Expressed ubiquitously TAB3 has more pronounced expression in tissues such as the liver suggesting its potential role in organ-specific functions.

Biological function summary

TAB3 influences multiple cellular signaling mechanisms contributing to the regulation of inflammatory responses and cell survival. It forms a part of important signaling complexes specifically the TAK1 complex which includes TAB1 and TAB2. Together this complex modulates pathways that are important for immune response and stress signaling in cells impacting the cell's ability to respond effectively to external signals.

Pathways

Research shows TAB3's involvement in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. As part of these pathways it interacts closely with other proteins including TAK1 orchestrating a coordinated cellular response to inflammatory and stress stimuli. The activity of these pathways is essential for maintaining proper cell signaling and gene expression under various physiological and pathological conditions.

Associated diseases and disorders

Studies connect TAB3 to inflammatory and autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Its role alongside TAK1 and NF-κB in these conditions highlights its significance in managing inflammatory responses. Understanding TAB3’s interactions and regulation could offer insights into therapeutic targets for managing these autoimmune and inflammatory diseases.