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AB96760

Anti-TACC2 antibody

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(2 Publications)

Rabbit Polyclonal TACC2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Transforming acidic coiled-coil-containing protein 2 aa 200-350.

View Alternative Names

Transforming acidic coiled-coil-containing protein 2, Anti-Zuai-1, AZU-1, TACC2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TACC2 antibody (AB96760)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TACC2 antibody (AB96760)

Immunohistochemical analysis of TACC2 in paraffin embedded Cal27 xenograft, using ab96760 antibody at a 1/100 dilution.

Western blot - Anti-TACC2 antibody (AB96760)
  • WB

Unknown

Western blot - Anti-TACC2 antibody (AB96760)

All lanes:

Western blot - Anti-TACC2 antibody (ab96760) at 1/1000 dilution

All lanes:

H1299 whole cell lysate at 30 µg

Predicted band size: 119 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Transforming acidic coiled-coil-containing protein 2 aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

O95359

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TACC2 also known as Transforming Acidic Coiled-Coil-Containing Protein 2 is a protein involved in cell cycle regulation. It has a molecular mass of approximately 146 kDa and is expressed in various tissues with notable expression in the brain. TACC2 interacts with microtubules stabilizing their structure which is essential for proper mitotic spindle formation during cell division. This stabilization facilitates accurate chromosome segregation a critical aspect of cellular replication.
Biological function summary

TACC2 plays a role in centrosome-related processes and is part of a multi-protein complex involved in microtubule dynamics. The protein is particularly important in neuronal cells where it contributes to maintaining proper cell architecture and neurogenesis. Studies have shown that TACC2 interacts with components involved in chromosomal stability ensuring the faithful transmission of genetic information during cell division thereby supporting cellular homeostasis.

Pathways

TACC2 is involved in cellular pathways such as the mitotic spindle assembly checkpoint and the Aurora kinase signaling pathway. It directly interacts with Aurora A a kinase that regulates mitotic entry and centrosome maturation. Aurora A works closely with TACC2 to promote the correct formation of the mitotic apparatus ensuring successful chromosomal alignment and segregation during cell division. This cooperation is essential to maintain genomic stability and prevent aneuploidy.

TACC2 relates to cancer and neurodevelopmental disorders. Abnormal expression or mutations in TACC2 are linked to certain cancer types often involving incomplete cytokinesis due to disrupted mitotic spindle function. It also interacts with proteins like Aurora A in these contexts which can contribute to oncogenic pathways. Furthermore alterations in TACC2 function are associated with neurodevelopmental disorders highlighting its critical role in neural tissue where failure to regulate microtubule dynamics can result in developmental abnormalities.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker.
See full target information Transforming acidic coiled-coil-containing protein 2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Stem cells international 2023:2826815 PubMed37964983

2023

A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories.

Applications

Unspecified application

Species

Unspecified reactive species

Guanghao Zhang,Xiaolong Xu,Luojiang Zhu,Sisi Li,Rundong Chen,Nan Lv,Zifu Li,Jing Wang,Qiang Li,Wang Zhou,Pengfei Yang,Jianmin Liu

Cellular and molecular gastroenterology and hepatology 9:277-293 PubMed31622786

2019

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Tomoya Iida,Daisuke Hirayama,Naoki Minami,Minoru Matsuura,Kohei Wagatsuma,Kentaro Kawakami,Kanna Nagaishi,Masanori Nojima,Hiroki Ikeuchi,Seiichi Hirota,Ryutaro Shirakawa,Hisanori Horiuchi,Hiroshi Nakase
View all publications
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Product promise

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