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AB138262

Anti-TACC3 antibody

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(3 Publications)

Rabbit Polyclonal TACC3 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TACC3.

View Alternative Names

ERIC1, TACC3, Transforming acidic coiled-coil-containing protein 3, ERIC-1

1 Images
Western blot - Anti-TACC3 antibody (AB138262)
  • WB

Unknown

Western blot - Anti-TACC3 antibody (AB138262)

All lanes:

Western blot - Anti-TACC3 antibody (ab138262) at 1/500 dilution

All lanes:

HepG2 cell lysate at 30 µg

Predicted band size: 90 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TACC3. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6A5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab138262 was affinity purified from rabbit antiserum by immunogenic peptide affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TACC3 also known as Transforming Acidic Coiled-Coil Containing Protein 3 is a microtubule-associated protein with a molecular weight of approximately 90 kDa. It plays an important role in stabilizing microtubules and is involved in mitotic spindle assembly. TACC3 is expressed in various tissues with high levels seen in proliferating cells such as embryonic cells and those in the testis. This expression pattern suggests it has important functions during cell division and development.
Biological function summary

TACC3 is part of a protein complex that contributes to mitosis. It collaborates with the Aurora A kinase and ch-TOG protein to ensure proper microtubule dynamics and spindle formation. This complex stabilizes kinetochore microtubules by connecting them to the centrosomes allowing accurate chromosome segregation during cell division. TACC3's actions are fundamental to cell cycle regulation and maintaining genomic stability.

Pathways

The role of TACC3 is linked to the cell cycle regulation and mitosis pathway. It interacts closely with the Aurora A kinase pathway playing a role in regulating centrosome maturation and spindle assembly. In these pathways proteins like TPX2 and PLK1 are also involved working alongside TACC3 to maintain the fidelity of cell division and ensure equal distribution of genetic material to daughter cells.

TACC3 is significantly implicated in various cancers. Abnormal expression levels of TACC3 have been associated with the development and progression of glioblastoma and breast cancer. It often exhibits partnerships with FGFR3 leading to oncogenic gene fusions that drive cancer cell growth and survival. Understanding TACC3 and its interactions remains important for developing targeted therapies in oncology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed : 21297582, PubMed : 23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed : 14767476).
See full target information TACC3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 297:101182 PubMed34534547

2021

A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Li,Yuhan Cai,Sihan Deng,Lin Yang,Na Liu,Xiaohan Chang,Lankai Jing,Yifeng Zhou,Hua Li

Oncology reports 42:2622-2634 PubMed31661142

2019

Identification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ‑based quantitative proteomics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyue Ren,Mingxu Luo,Jinzhong Chen,Yanming Zhou,Xiumei Li,Yanyan Zhan,Dongyan Shen,Bo Chen

Investigative ophthalmology & visual science 58:4925-4933 PubMed28973338

2017

Histologic Characterization of Retina Neuroglia Modifications in Diabetic Zucker Diabetic Fatty Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Ivan Fernandez-Bueno,Robert Jones,Laura Soriano-Romaní,Antonio López-García,Orla Galvin,Sharon Cheetham,Yolanda Diebold
View all publications
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