AB89744

Anti-TACI antibody [MM0562-9D22]

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(1 Publication)

Mouse Monoclonal TACI antibody. Suitable for WB, FuncS (Neut/Block), IHC-Fr and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TNFRSF13B.

View Alternative Names

CD267, TACI, TNFRSF13B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0562-9D22

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-Fr, WB, FuncS (Neut/Block)

applications

Immunogen

Recombinant Fragment Protein within Human TNFRSF13B. The exact immunogen used to generate this antibody is proprietary information.

O14836

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Reactivity data

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Product details

Reconstituted antibody should be aliquoted and can be stored frozen at < -20°C for at least six months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

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Properties and storage information

Form

Lyophilized

Reconstitution

reconstitute with PBS at 200µL

Purification technique

Affinity purification Protein G

Purification notes

The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 μm filter.

Storage buffer

Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-80°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Transmembrane Activator and CAML Interactor known as TACI also goes by the names TNFRSF13B and CD267. TACI is a receptor with a molecular weight of approximately 33 kDa. It is expressed on B cells a type of lymphocyte and to some extent on activated T cells. This receptor plays a part in the immune system helping manage the production and function of certain antibodies.

Biological function summary

TACI involves the regulation of B cell function and survival. It binds to two ligands APRIL and BAFF and TACI is not part of any larger complex. Upon ligand binding TACI can promote antibody class-switching which adjusts the type of antibody that B cells produce. This action supports the immune response by allowing the body to adapt to different pathogens effectively.

Pathways

Immune responses involve TACI in the BAFF-APRIL signaling pathway. The interplay between TACI and its ligands influences the NF-kB signaling cascade leading to B cell proliferation and survival. TACI interacts with other proteins such as BCMA and BAFF-R which are important in regulating B cell homeostasis and function ensuring balanced and effective immune responses.

Aberrant TACI function contributes to conditions like Common Variable Immunodeficiency (CVID) and Systemic Lupus Erythematosus (SLE). In CVID mutations in the TACI gene may lead to impaired antibody production resulting in frequent infections. In the context of SLE TACI's interactions with BAFF and APRIL can contribute to the overactivation of B cells causing autoimmune characteristics of the disease. TACI's role in these conditions makes it a focus for studying therapeutic interventions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

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Target data

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

See full target information TNFRSF13B

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of respiratory and critical care medicine 190:1373-82 PubMed25350863

2014

IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

David J Jackson,Heidi Makrinioti,Batika M J Rana,Betty W H Shamji,Maria-Belen Trujillo-Torralbo,Joseph Footitt, Jerico Del-Rosario,Aurica G Telcian,Alexandra Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,James Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A Stanciu,Musa Khaitov,Nathan W Bartlett,Michael R Edwards,Onn Min Kon,Patrick Mallia,Nikolaos G Papadopoulos,Cezmi A Akdis,John Westwick,Matthew J Edwards,David J Cousins,Ross P Walton,Sebastian L Johnston

View all publications

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