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AB238759

Anti-TAF1B antibody

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(1 Publication)

Rabbit Polyclonal TAF1B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAF1B aa 350 to C-terminus.

View Alternative Names

TATA box-binding protein-associated factor RNA polymerase I subunit B, RNA polymerase I-specific TBP-associated factor 63 kDa, TATA box-binding protein-associated factor 1B, Transcription initiation factor SL1/TIF-IB subunit B, TAFI63, TBP-associated factor 1B, TAF1B

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAF1B antibody (AB238759)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAF1B antibody (AB238759)

Paraffin-embedded human colon cancer tissue stained for TAF1B using ab238759 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TAF1B aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q53T94

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Cynomolgus monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAF1B also known as TATA box binding protein-associated factor RNA polymerase I subunit B is a component of the transcription machinery. It has a molecular weight of approximately 63 kDa. TAF1B plays an important role in the formation of the transcription initiation complex for RNA polymerase I. Its expression occurs mainly in the nucleolus of eukaryotic cells where it directly interacts with other transcription factors.
Biological function summary

TAF1B regulates the initiation of rRNA transcription. It forms part of the SL1 complex which is essential for recognizing the rDNA promoter and facilitating the binding of RNA polymerase I. The SL1 complex which includes TAF1B TBP TAF1A and TAF1C ensures the accuracy of rRNA gene transcription. This assembly directly influences ribosomal RNA (rRNA) synthesis a critical process in ribosome biogenesis in cells.

Pathways

TAF1B plays a major role in the ribosome biogenesis and cell growth pathways. Its function within the SL1 complex helps initiate the transcription of rRNA genes by RNA polymerase I. TAF1B collaborates with proteins such as TAF1A and TAF1C in these pathways. These pathways are fundamental for cell proliferation and protein synthesis emphasizing the importance of TAF1B in maintaining cellular function.

TAF1B associates with conditions such as cancer and ribosomopathies. Dysregulation of rRNA synthesis due to anomalies in TAF1B can lead to uncontrolled cellular growth a hallmark of cancer. Alterations in TAF1B's function have also been linked to ribosomal biogenesis disorders. When TAF1B and associated proteins in the SL1 complex malfunction it can result in improper ribosome formation contributing to various pathological states.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
See full target information TAF1B
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed38791213

2024

Distinctiveness of Femoral and Acetabular Mesenchymal Stem and Progenitor Populations in Patients with Primary and Secondary Hip Osteoarthritis Due to Developmental Dysplasia.

Applications

Unspecified application

Species

Unspecified reactive species

Mihovil Plečko,Nataša Kovačić,Danka Grčević,Alan Šućur,Andreja Vukasović Barišić,Tea Duvančić,Ivan Bohaček,Domagoj Delimar
View all publications
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Product promise

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