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AB204902

Anti-TAGLN3 antibody

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(1 Publication)

Rabbit Polyclonal TAGLN3 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TAGLN3 aa 1-50.
3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAGLN3 antibody (AB204902)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAGLN3 antibody (AB204902)

Immunohistochemical analysis in human pancreas tissue labeling TAGLN3 (low expression) with ab204902 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAGLN3 antibody (AB204902)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TAGLN3 antibody (AB204902)

Immunohistochemical analysis in human cerebral cortex tissue labeling TAGLN3 (high expression) with ab204902 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-TAGLN3 antibody (AB204902)
  • WB

Supplier Data

Western blot - Anti-TAGLN3 antibody (AB204902)

All lanes:

Western blot - Anti-TAGLN3 antibody (ab204902) at 0.4 µg/mL

All lanes:

Human cerebral cortex tissue

Predicted band size: 22 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TAGLN3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q9UI15

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Transgelin-3 also known as TAGLN3 is a member of the calponin family of actin-binding proteins. It plays a role in the reorganization of the actin cytoskeleton which is important for cellular movement and shape. TAGLN3 contains 201 amino acids giving it an approximate molecular mass of 22.1 kDa. In terms of expression TAGLN3 is mostly found in neural tissues including the brain where it is associated with the development and function of neurons.
Biological function summary

TAGLN3 influences neural development and synaptic plasticity contributing to communication between neurons. This protein does not typically function as part of larger complexes but it associates closely with cytoskeletal components noting its importance in maintaining neuronal architecture. TAGLN3's effect on actin dynamics supports both the stabilization of neural structures and facilitation of structural plasticity required for learning and memory processes.

Pathways

TAGLN3 interacts closely with intracellular signaling related to actin-mediated processes. It engages in pathways like the RhoA/ROCK signaling influencing cell morphology and motility by mediating actin filament assembly. Additionally TAGLN3 exhibits interactions with cofilin a known regulator of actin dynamics suggesting a cooperative role in modulating cytoskeletal rearrangement important for functional changes in neural cells.

TAGLN3 has been linked to neurodegenerative conditions and certain types of cancer. Dysregulation of TAGLN3 expression may impact neuronal integrity and has been observed in Alzheimer's disease where it potentially contributes to pathogenesis through altered cytoskeletal dynamics. Furthermore aberrant expression of TAGLN3 in cancer particularly glioblastoma suggests a role in tumor progression. In these conditions TAGLN3 often appears alongside proteins like tau in Alzheimer's and β-catenin in glioblastoma likely influencing disease mechanisms through its interactions with the actin cytoskeleton.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information TAGLN3

Alternative Names

NP25, TAGLN3, Transgelin-3, Neuronal protein 22, Neuronal protein NP25, NP22
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

International journal of molecular sciences 21: PubMed33322837

2020

The Reprimo-Like Gene Is an Epigenetic-Mediated Tumor Suppressor and a Candidate Biomarker for the Non-Invasive Detection of Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

María Alejandra Alarcón,Wilda Olivares,Miguel Córdova-Delgado,Matías Muñoz-Medel,Tomas de Mayo,Gonzalo Carrasco-Aviño,Ignacio Wichmann,Natalia Landeros,Julio Amigo,Enrique Norero,Franz Villarroel-Espíndola,Arnoldo Riquelme,Marcelo Garrido,Gareth I Owen,Alejandro H Corvalán
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
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