JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB155195

Anti-Tal1 antibody

4

(1 Review)

|

(6 Publications)

Rabbit Polyclonal TAL1 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human TAL1 aa 250-350.

View Alternative Names

BHLHA17, SCL, TCL5, TAL1, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, Stem cell protein, T-cell leukemia/lymphoma protein 5, bHLHa17

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Immunohistochemical analysis of paraffin-embedded A549 xenograft tissue staining Tal1 with ab155195 at 1/100 dilution.

Antigen Retrieval : EDTA based buffer, pH 8.0, 15min.

Immunoprecipitation - Anti-Tal1 antibody (AB155195)
  • IP

Supplier Data

Immunoprecipitation - Anti-Tal1 antibody (AB155195)

TAL1 antibody immunoprecipitates TAL1 protein in IP experiments.

IP Sample : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate.

A : HEK-293T whole cell lysate. 40 μg.

B : Control with 2 μg of preimmune rabbit IgG.

C : Immunoprecipitate of TAL1 protein by 2 μg of ab155195.

12% SDS-PAGE

The immunoprecipitated TAL1 protein was detected by ab155195 at 1/1000 dilution, followed by anti-rabbit IgG antibody.

All lanes:

Immunoprecipitation - Anti-Tal1 antibody (ab155195)

Predicted band size: 34 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tal1 antibody (AB155195)

Immunohistochemical analysis of paraffin-embedded mouse spleen tissue staining Tal1 at cytosol and nucleus with ab155195 at 1/500 dilution.

Antigen Retrieval : EDTA based buffer, pH 8.0, 15min.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IP, IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human TAL1 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

P17542

style
left-column

Complementary Products

Primary Antibodies

AB91652

Anti-LMO2 antibody [EP3257]

RabMAb|Recombinant

Immunoprecipitation - Anti-LMO2 antibody [EP3257] (AB91652)

  • 0
  • 0
Primary Antibodies

AB227835

Anti-PU.1/Spi1 antibody [EPR22624-20] - ChIP Grade

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-PU.1/Spi1 antibody [EPR22624-20] - ChIP Grade (AB227835)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB300613

Anti-GATA1 antibody [EPR26488-109]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GATA1 antibody [EPR26488-109] (AB300613)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/100 - 1/500", "IP-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" }, "Mouse": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p>Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein Tal1 also known as T-cell acute lymphocytic leukemia protein 1 and SCL (stem cell leukemia) is a transcription factor of about 34 kDa. It plays a role in the regulation of hematopoiesis. Tal1 is expressed in hematopoietic cells and tissues like bone marrow thymus and fetal liver. It binds to specific DNA sequences to regulate gene expression essential for the development and function of blood cells.
Biological function summary

The Tal1 protein controls the differentiation and proliferation of hematopoietic stem cells and progenitor cells. It participates as a part of a multiprotein complex involving other transcription factors and cofactors such as GATA-1 and LMO2 which modulates gene expression during blood cell lineage commitment. Through these interactions Tal1 influences both myeloid and lymphoid lineage differentiation.

Pathways

Tal1 acts as an important regulator in the hematopoietic development pathway and is critical for the endothelial-to-hematopoietic transition. This transition is supported by interaction with the E2A proteins which stabilize the formation of the transcription complex needed for lineage-specific gene regulation. Tal1 also plays a role in the VEGF signaling pathway impacting vascular and blood development processes.

Tal1 significantly associates with T-cell acute lymphoblastic leukemia (T-ALL) and some types of anemia. Its deregulation often through chromosomal translocations or overexpression results in aberrant hematopoiesis contributing to leukemogenesis. In T-ALL Tal1 can interact with oncogenic proteins like LMO1 and LMO2 leading to the disruption of normal T-cell development and proliferation highlighting its involvement in the disease's molecular pathology.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).
See full target information TAL1
style
left-column

Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:30552 PubMed40836054

2025

Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration.

Applications

Unspecified application

Species

Unspecified reactive species

Doru Kwon,Hyun Woo Park,Byung Soh Min,Junjeong Choi

Journal of translational medicine 23:719 PubMed40598260

2025

Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6.

Applications

Unspecified application

Species

Unspecified reactive species

Hanning Zhang,Ruru Li,Qianqian Huo,Li Li,Min Li,Shunxin Hu,Changjie Ren,Zongyin Wu,Chenghu Zhang

Cancers 15: PubMed37174017

2023

Expression of Hemangioblast Proteins in von Hippel-Lindau Disease Related Tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Evelynn Vergauwen,Ramses Forsyth,Alexander Vortmeyer,Sven Gläsker

Scientific reports 12:7226 PubMed35508511

2022

The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshihiro Yamada,Yi Zhong,Shiho Miki,Akiko Taura,Terence H Rabbitts

Leukemia 34:746-758 PubMed31676828

2019

LSD1-mediated repression of GFI1 super-enhancer plays an essential role in erythroleukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Goichi Tatsumi,Masahiro Kawahara,Ryusuke Yamamoto,Masakatsu Hishizawa,Katsuyuki Kito,Takayoshi Suzuki,Akifumi Takaori-Kondo,Akira Andoh

Genome biology 20:192 PubMed31500663

2019

CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhu,Nan Liu,Stuart H Orkin,Guo-Cheng Yuan
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com